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PRECIPITIN RESPONSE IN THE BLOOD OF RABBITS FOLLOWING SUBARACHNOID INJECTIONS OF HORSE SERUM

1. Rabbits which have received a single dose of normal horse serum in the subarachnoid space produce precipitins in the blood in greater abundance, of higher titer, and persisting longer than those in control rabbits which have received a similar injection intravenously. 2. Repeated subarachnoid inj...

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Detalles Bibliográficos
Autor principal: Alexander, Harry L.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1921
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2128197/
https://www.ncbi.nlm.nih.gov/pubmed/19868510
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author Alexander, Harry L.
author_facet Alexander, Harry L.
author_sort Alexander, Harry L.
collection PubMed
description 1. Rabbits which have received a single dose of normal horse serum in the subarachnoid space produce precipitins in the blood in greater abundance, of higher titer, and persisting longer than those in control rabbits which have received a similar injection intravenously. 2. Repeated subarachnoid injections of normal horse serum in rabbits induce precipitins in the blood early. These may appear in high titer as soon as 1 week after the initial injection, whereas in rabbits similarly treated intravenously no precipitins are found at this time. They may appear a few days afterward and reach a high titer. 3. No anaphylactic manifestations occurred in rabbits treated repeatedly with subarachnoid injections of normal horse serum when the precipitin content of the blood was high. 4. Anaphylactins, as determined by passive transfer of anaphylaxis, were demonstrated in sera with high precipitin content. 5. These experiments may explain clinical evidences of anaphylaxis, observed when an initial intravenous injection of horse serum followed a series of intraspinal injections of such serum.
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spelling pubmed-21281972008-04-18 PRECIPITIN RESPONSE IN THE BLOOD OF RABBITS FOLLOWING SUBARACHNOID INJECTIONS OF HORSE SERUM Alexander, Harry L. J Exp Med Article 1. Rabbits which have received a single dose of normal horse serum in the subarachnoid space produce precipitins in the blood in greater abundance, of higher titer, and persisting longer than those in control rabbits which have received a similar injection intravenously. 2. Repeated subarachnoid injections of normal horse serum in rabbits induce precipitins in the blood early. These may appear in high titer as soon as 1 week after the initial injection, whereas in rabbits similarly treated intravenously no precipitins are found at this time. They may appear a few days afterward and reach a high titer. 3. No anaphylactic manifestations occurred in rabbits treated repeatedly with subarachnoid injections of normal horse serum when the precipitin content of the blood was high. 4. Anaphylactins, as determined by passive transfer of anaphylaxis, were demonstrated in sera with high precipitin content. 5. These experiments may explain clinical evidences of anaphylaxis, observed when an initial intravenous injection of horse serum followed a series of intraspinal injections of such serum. The Rockefeller University Press 1921-03-31 /pmc/articles/PMC2128197/ /pubmed/19868510 Text en Copyright © Copyright, 1921, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Alexander, Harry L.
PRECIPITIN RESPONSE IN THE BLOOD OF RABBITS FOLLOWING SUBARACHNOID INJECTIONS OF HORSE SERUM
title PRECIPITIN RESPONSE IN THE BLOOD OF RABBITS FOLLOWING SUBARACHNOID INJECTIONS OF HORSE SERUM
title_full PRECIPITIN RESPONSE IN THE BLOOD OF RABBITS FOLLOWING SUBARACHNOID INJECTIONS OF HORSE SERUM
title_fullStr PRECIPITIN RESPONSE IN THE BLOOD OF RABBITS FOLLOWING SUBARACHNOID INJECTIONS OF HORSE SERUM
title_full_unstemmed PRECIPITIN RESPONSE IN THE BLOOD OF RABBITS FOLLOWING SUBARACHNOID INJECTIONS OF HORSE SERUM
title_short PRECIPITIN RESPONSE IN THE BLOOD OF RABBITS FOLLOWING SUBARACHNOID INJECTIONS OF HORSE SERUM
title_sort precipitin response in the blood of rabbits following subarachnoid injections of horse serum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2128197/
https://www.ncbi.nlm.nih.gov/pubmed/19868510
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