Cargando…
THE BILIARY OBSTRUCTION REQUIRED TO PRODUCE JAUNDICE
The bile ducts from three-quarters of the liver substance in dogs and monkeys can be obstructed without any clinical evidence developing of pigment or cholate accumulation in the organism. And in the dog nineteen-twentieths of the liver substance can be placed in stasis without the occurrence of tis...
Autores principales: | , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
1921
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2128305/ https://www.ncbi.nlm.nih.gov/pubmed/19868532 |
_version_ | 1782142039665672192 |
---|---|
author | McMaster, Philip D. Rous, Peyton |
author_facet | McMaster, Philip D. Rous, Peyton |
author_sort | McMaster, Philip D. |
collection | PubMed |
description | The bile ducts from three-quarters of the liver substance in dogs and monkeys can be obstructed without any clinical evidence developing of pigment or cholate accumulation in the organism. And in the dog nineteen-twentieths of the liver substance can be placed in stasis without the occurrence of tissue icterus such as regularly follows total obstruction in this animal. There is no reason to suppose that this will not be found true in the monkey as well. Always a local obstruction results sooner or later in atrophy of the affected tissue with compensatory hypertrophy elsewhere. Thus as time passes the derangement of function produced by the sudden stasis is progressively lessened. The plasma of the dog and monkey, unlike that of man, is normally free from bilirubin, and this pigment so readily escapes from the blood into the urine that bilirubinuria is often to be found in the dog in the absence of bilirubinemia, while the latter is never met with alone in either animal. It follows that in both species the renal threshold for bilirubin is much lower than in man,—if indeed one can be said to exist at all. The amount of biliary obstruction required to produce jaundice in human beings is probably as great as in the experimental animals with which we have dealt. The clinical jaundice encountered in association with local liver lesions should be viewed not as the result of local bile resorption, but as due to a general injury to the hepatic parenchyma or ducts, or to blood destruction. |
format | Text |
id | pubmed-2128305 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1921 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21283052008-04-18 THE BILIARY OBSTRUCTION REQUIRED TO PRODUCE JAUNDICE McMaster, Philip D. Rous, Peyton J Exp Med Article The bile ducts from three-quarters of the liver substance in dogs and monkeys can be obstructed without any clinical evidence developing of pigment or cholate accumulation in the organism. And in the dog nineteen-twentieths of the liver substance can be placed in stasis without the occurrence of tissue icterus such as regularly follows total obstruction in this animal. There is no reason to suppose that this will not be found true in the monkey as well. Always a local obstruction results sooner or later in atrophy of the affected tissue with compensatory hypertrophy elsewhere. Thus as time passes the derangement of function produced by the sudden stasis is progressively lessened. The plasma of the dog and monkey, unlike that of man, is normally free from bilirubin, and this pigment so readily escapes from the blood into the urine that bilirubinuria is often to be found in the dog in the absence of bilirubinemia, while the latter is never met with alone in either animal. It follows that in both species the renal threshold for bilirubin is much lower than in man,—if indeed one can be said to exist at all. The amount of biliary obstruction required to produce jaundice in human beings is probably as great as in the experimental animals with which we have dealt. The clinical jaundice encountered in association with local liver lesions should be viewed not as the result of local bile resorption, but as due to a general injury to the hepatic parenchyma or ducts, or to blood destruction. The Rockefeller University Press 1921-05-31 /pmc/articles/PMC2128305/ /pubmed/19868532 Text en Copyright © Copyright, 1921, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article McMaster, Philip D. Rous, Peyton THE BILIARY OBSTRUCTION REQUIRED TO PRODUCE JAUNDICE |
title | THE BILIARY OBSTRUCTION REQUIRED TO PRODUCE JAUNDICE |
title_full | THE BILIARY OBSTRUCTION REQUIRED TO PRODUCE JAUNDICE |
title_fullStr | THE BILIARY OBSTRUCTION REQUIRED TO PRODUCE JAUNDICE |
title_full_unstemmed | THE BILIARY OBSTRUCTION REQUIRED TO PRODUCE JAUNDICE |
title_short | THE BILIARY OBSTRUCTION REQUIRED TO PRODUCE JAUNDICE |
title_sort | biliary obstruction required to produce jaundice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2128305/ https://www.ncbi.nlm.nih.gov/pubmed/19868532 |
work_keys_str_mv | AT mcmasterphilipd thebiliaryobstructionrequiredtoproducejaundice AT rouspeyton thebiliaryobstructionrequiredtoproducejaundice AT mcmasterphilipd biliaryobstructionrequiredtoproducejaundice AT rouspeyton biliaryobstructionrequiredtoproducejaundice |