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STUDIES BASED ON A MALIGNANT TUMOR OF THE RABBIT : II. PRIMARY TRANSPLANTATION AND ELIMINATION OF A COEXISTING SYPHILITIC INFECTION.

Several attempts were made to transplant a spontaneous malignant tumor in a syphilitic rabbit before a method was devised which proved successful. Subcutaneous and intracutaneous inoculations were unsuccessful on account of the vigorous granulomatous reaction which was aroused by the introduction of...

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Detalles Bibliográficos
Autores principales: Pearce, Louise, Brown, Wade H.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1923
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2128357/
https://www.ncbi.nlm.nih.gov/pubmed/19868748
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author Pearce, Louise
Brown, Wade H.
author_facet Pearce, Louise
Brown, Wade H.
author_sort Pearce, Louise
collection PubMed
description Several attempts were made to transplant a spontaneous malignant tumor in a syphilitic rabbit before a method was devised which proved successful. Subcutaneous and intracutaneous inoculations were unsuccessful on account of the vigorous granulomatous reaction which was aroused by the introduction of tumor fragments into these tissues. This difficulty was overcome by the use of intratesticular inoculations. With this method, a good growth was obtained in practically all animals. It appeared possible, however, that a syphilitic infection had been transmitted along with the tumor, and hence treatment with arsphenamine was instituted as a means of eliminating this infection. A study of the transplanted tumor in the first and second generations showed that it possessed a high degree of malignancy. Metastases occurred at an early period in the majority of animals, and while some of them appeared to recover, the indications were that more than 50 per cent might be expected to succumb to the effects of the tumor growth within a period of 6 to 7 months. The method of intratesticular inoculation now in use is described in detail.
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spelling pubmed-21283572008-04-18 STUDIES BASED ON A MALIGNANT TUMOR OF THE RABBIT : II. PRIMARY TRANSPLANTATION AND ELIMINATION OF A COEXISTING SYPHILITIC INFECTION. Pearce, Louise Brown, Wade H. J Exp Med Article Several attempts were made to transplant a spontaneous malignant tumor in a syphilitic rabbit before a method was devised which proved successful. Subcutaneous and intracutaneous inoculations were unsuccessful on account of the vigorous granulomatous reaction which was aroused by the introduction of tumor fragments into these tissues. This difficulty was overcome by the use of intratesticular inoculations. With this method, a good growth was obtained in practically all animals. It appeared possible, however, that a syphilitic infection had been transmitted along with the tumor, and hence treatment with arsphenamine was instituted as a means of eliminating this infection. A study of the transplanted tumor in the first and second generations showed that it possessed a high degree of malignancy. Metastases occurred at an early period in the majority of animals, and while some of them appeared to recover, the indications were that more than 50 per cent might be expected to succumb to the effects of the tumor growth within a period of 6 to 7 months. The method of intratesticular inoculation now in use is described in detail. The Rockefeller University Press 1923-04-30 /pmc/articles/PMC2128357/ /pubmed/19868748 Text en Copyright © Copyright, 1923, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Pearce, Louise
Brown, Wade H.
STUDIES BASED ON A MALIGNANT TUMOR OF THE RABBIT : II. PRIMARY TRANSPLANTATION AND ELIMINATION OF A COEXISTING SYPHILITIC INFECTION.
title STUDIES BASED ON A MALIGNANT TUMOR OF THE RABBIT : II. PRIMARY TRANSPLANTATION AND ELIMINATION OF A COEXISTING SYPHILITIC INFECTION.
title_full STUDIES BASED ON A MALIGNANT TUMOR OF THE RABBIT : II. PRIMARY TRANSPLANTATION AND ELIMINATION OF A COEXISTING SYPHILITIC INFECTION.
title_fullStr STUDIES BASED ON A MALIGNANT TUMOR OF THE RABBIT : II. PRIMARY TRANSPLANTATION AND ELIMINATION OF A COEXISTING SYPHILITIC INFECTION.
title_full_unstemmed STUDIES BASED ON A MALIGNANT TUMOR OF THE RABBIT : II. PRIMARY TRANSPLANTATION AND ELIMINATION OF A COEXISTING SYPHILITIC INFECTION.
title_short STUDIES BASED ON A MALIGNANT TUMOR OF THE RABBIT : II. PRIMARY TRANSPLANTATION AND ELIMINATION OF A COEXISTING SYPHILITIC INFECTION.
title_sort studies based on a malignant tumor of the rabbit : ii. primary transplantation and elimination of a coexisting syphilitic infection.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2128357/
https://www.ncbi.nlm.nih.gov/pubmed/19868748
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