PROTECTION AGAINST TYPHOID-LIKE INFECTIONS BY VACCINATION : AN EXPERIMENTAL STUDY.

1. A natural infection of guinea pigs with the "mutton" strain of Bacillus aertrycke was used to test the protective power of vaccination against the typhoid group of infections. 2. Under the conditions of the experiment, complete protection was secured by vaccination with full strength fr...

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Detalles Bibliográficos
Autores principales: Nichols, Henry J., Stimmel, Clarence O.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1923
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2128442/
https://www.ncbi.nlm.nih.gov/pubmed/19868790
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author Nichols, Henry J.
Stimmel, Clarence O.
author_facet Nichols, Henry J.
Stimmel, Clarence O.
author_sort Nichols, Henry J.
collection PubMed
description 1. A natural infection of guinea pigs with the "mutton" strain of Bacillus aertrycke was used to test the protective power of vaccination against the typhoid group of infections. 2. Under the conditions of the experiment, complete protection was secured by vaccination with full strength fresh saline vaccine, while 100 per cent of deaths occurred among the controls. 3. The immunity acquired is variable and depends on the number of organisms injected. 4. Vaccine kept 10 to 14 months gave less protection than vaccine 8 months old and under. 5. Saline vaccine was more effective than lipovaccine, sensitized vaccine, or supernatant fluid vaccine. 6. Resuspended vaccine was as effective as the original vaccine. 7. In one experiment, group vaccine, made of typhoid Para A and Para B bacilli, was as effective as the original specific vaccine.
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spelling pubmed-21284422008-04-18 PROTECTION AGAINST TYPHOID-LIKE INFECTIONS BY VACCINATION : AN EXPERIMENTAL STUDY. Nichols, Henry J. Stimmel, Clarence O. J Exp Med Article 1. A natural infection of guinea pigs with the "mutton" strain of Bacillus aertrycke was used to test the protective power of vaccination against the typhoid group of infections. 2. Under the conditions of the experiment, complete protection was secured by vaccination with full strength fresh saline vaccine, while 100 per cent of deaths occurred among the controls. 3. The immunity acquired is variable and depends on the number of organisms injected. 4. Vaccine kept 10 to 14 months gave less protection than vaccine 8 months old and under. 5. Saline vaccine was more effective than lipovaccine, sensitized vaccine, or supernatant fluid vaccine. 6. Resuspended vaccine was as effective as the original vaccine. 7. In one experiment, group vaccine, made of typhoid Para A and Para B bacilli, was as effective as the original specific vaccine. The Rockefeller University Press 1923-08-31 /pmc/articles/PMC2128442/ /pubmed/19868790 Text en Copyright © Copyright, 1923, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Nichols, Henry J.
Stimmel, Clarence O.
PROTECTION AGAINST TYPHOID-LIKE INFECTIONS BY VACCINATION : AN EXPERIMENTAL STUDY.
title PROTECTION AGAINST TYPHOID-LIKE INFECTIONS BY VACCINATION : AN EXPERIMENTAL STUDY.
title_full PROTECTION AGAINST TYPHOID-LIKE INFECTIONS BY VACCINATION : AN EXPERIMENTAL STUDY.
title_fullStr PROTECTION AGAINST TYPHOID-LIKE INFECTIONS BY VACCINATION : AN EXPERIMENTAL STUDY.
title_full_unstemmed PROTECTION AGAINST TYPHOID-LIKE INFECTIONS BY VACCINATION : AN EXPERIMENTAL STUDY.
title_short PROTECTION AGAINST TYPHOID-LIKE INFECTIONS BY VACCINATION : AN EXPERIMENTAL STUDY.
title_sort protection against typhoid-like infections by vaccination : an experimental study.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2128442/
https://www.ncbi.nlm.nih.gov/pubmed/19868790
work_keys_str_mv AT nicholshenryj protectionagainsttyphoidlikeinfectionsbyvaccinationanexperimentalstudy
AT stimmelclarenceo protectionagainsttyphoidlikeinfectionsbyvaccinationanexperimentalstudy

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