THE EFFECT OF DIGESTIVE JUICES ON THE POTENCY OF BOTULINUS TOXIN

Botulinus toxin resists a degree of acidity equivalent to that of the stomach even when exposed thereto for 24 hours at 37°C. It is less resistant to alkali, however, as shown by the fact that in a medium of weakly alkaline reaction its potency is reduced to less than one-tenth in 24 hours. It is un...

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Detalles Bibliográficos
Autores principales: Bronfenbrenner, Jacques J., Schlesinger, Monroe J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1924
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2128515/
https://www.ncbi.nlm.nih.gov/pubmed/19868861
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author Bronfenbrenner, Jacques J.
Schlesinger, Monroe J.
author_facet Bronfenbrenner, Jacques J.
Schlesinger, Monroe J.
author_sort Bronfenbrenner, Jacques J.
collection PubMed
description Botulinus toxin resists a degree of acidity equivalent to that of the stomach even when exposed thereto for 24 hours at 37°C. It is less resistant to alkali, however, as shown by the fact that in a medium of weakly alkaline reaction its potency is reduced to less than one-tenth in 24 hours. It is unaffected by peptic and tryptic digestion. Because of its instability in mildly alkaline solutions and resistance to acid, there is reason to believe that the toxin is in the main absorbed from the upper portion of the digestive tract; that is to say, from the stomach and upper duodenum.
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spelling pubmed-21285152008-04-18 THE EFFECT OF DIGESTIVE JUICES ON THE POTENCY OF BOTULINUS TOXIN Bronfenbrenner, Jacques J. Schlesinger, Monroe J. J Exp Med Article Botulinus toxin resists a degree of acidity equivalent to that of the stomach even when exposed thereto for 24 hours at 37°C. It is less resistant to alkali, however, as shown by the fact that in a medium of weakly alkaline reaction its potency is reduced to less than one-tenth in 24 hours. It is unaffected by peptic and tryptic digestion. Because of its instability in mildly alkaline solutions and resistance to acid, there is reason to believe that the toxin is in the main absorbed from the upper portion of the digestive tract; that is to say, from the stomach and upper duodenum. The Rockefeller University Press 1924-03-31 /pmc/articles/PMC2128515/ /pubmed/19868861 Text en Copyright © Copyright, 1924, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Bronfenbrenner, Jacques J.
Schlesinger, Monroe J.
THE EFFECT OF DIGESTIVE JUICES ON THE POTENCY OF BOTULINUS TOXIN
title THE EFFECT OF DIGESTIVE JUICES ON THE POTENCY OF BOTULINUS TOXIN
title_full THE EFFECT OF DIGESTIVE JUICES ON THE POTENCY OF BOTULINUS TOXIN
title_fullStr THE EFFECT OF DIGESTIVE JUICES ON THE POTENCY OF BOTULINUS TOXIN
title_full_unstemmed THE EFFECT OF DIGESTIVE JUICES ON THE POTENCY OF BOTULINUS TOXIN
title_short THE EFFECT OF DIGESTIVE JUICES ON THE POTENCY OF BOTULINUS TOXIN
title_sort effect of digestive juices on the potency of botulinus toxin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2128515/
https://www.ncbi.nlm.nih.gov/pubmed/19868861
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