ON THE SPECIFICITY OF AGGLUTININS AND PRECIPITINS

The results of the partial saturation of precipitins with antigens related in derivation to the homologous one give no conclusive evidence of the regular existence in a single immune serum of multiple antibodies which act specifically on various chemical groups of the antigenic proteins. It seems po...

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Detalles Bibliográficos
Autores principales: Landsteiner, K., van der Scheer, James
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1924
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2128557/
https://www.ncbi.nlm.nih.gov/pubmed/19868906
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author Landsteiner, K.
van der Scheer, James
author_facet Landsteiner, K.
van der Scheer, James
author_sort Landsteiner, K.
collection PubMed
description The results of the partial saturation of precipitins with antigens related in derivation to the homologous one give no conclusive evidence of the regular existence in a single immune serum of multiple antibodies which act specifically on various chemical groups of the antigenic proteins. It seems possible to explain at least a part of the facts by the assumption that a single antibody will react to different degrees with several similar substances. By the partial absorption of hemagglutinins with heterologous blood, specific fractions were obtained. By such means one may readily differentiate the blood of related species, even when precipitins show but little difference. The peculiarities in specificity manifested by precipitinogens and agglutinogens suggest an essential difference in the chemical structures which determine the specificity of the two kinds of antigens.
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spelling pubmed-21285572008-04-18 ON THE SPECIFICITY OF AGGLUTININS AND PRECIPITINS Landsteiner, K. van der Scheer, James J Exp Med Article The results of the partial saturation of precipitins with antigens related in derivation to the homologous one give no conclusive evidence of the regular existence in a single immune serum of multiple antibodies which act specifically on various chemical groups of the antigenic proteins. It seems possible to explain at least a part of the facts by the assumption that a single antibody will react to different degrees with several similar substances. By the partial absorption of hemagglutinins with heterologous blood, specific fractions were obtained. By such means one may readily differentiate the blood of related species, even when precipitins show but little difference. The peculiarities in specificity manifested by precipitinogens and agglutinogens suggest an essential difference in the chemical structures which determine the specificity of the two kinds of antigens. The Rockefeller University Press 1924-06-30 /pmc/articles/PMC2128557/ /pubmed/19868906 Text en Copyright © Copyright, 1924, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Landsteiner, K.
van der Scheer, James
ON THE SPECIFICITY OF AGGLUTININS AND PRECIPITINS
title ON THE SPECIFICITY OF AGGLUTININS AND PRECIPITINS
title_full ON THE SPECIFICITY OF AGGLUTININS AND PRECIPITINS
title_fullStr ON THE SPECIFICITY OF AGGLUTININS AND PRECIPITINS
title_full_unstemmed ON THE SPECIFICITY OF AGGLUTININS AND PRECIPITINS
title_short ON THE SPECIFICITY OF AGGLUTININS AND PRECIPITINS
title_sort on the specificity of agglutinins and precipitins
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2128557/
https://www.ncbi.nlm.nih.gov/pubmed/19868906
work_keys_str_mv AT landsteinerk onthespecificityofagglutininsandprecipitins
AT vanderscheerjames onthespecificityofagglutininsandprecipitins

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