THE SOLUBLE SPECIFIC SUBSTANCE OF PNEUMOCOCCUS : SECOND PAPER.

1. The method for the concentration and purification of the soluble specific substance of Pneumococcus has been improved. 2. Highly purified specific substance of Type II pneumococcus of polysaccharide nature is shown to be recovered essentially unchanged after precipitation by immune serum, by uran...

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Detalles Bibliográficos
Autores principales: Heidelberger, Michael, Avery, Oswald T.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1924
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2128576/
https://www.ncbi.nlm.nih.gov/pubmed/19868919
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author Heidelberger, Michael
Avery, Oswald T.
author_facet Heidelberger, Michael
Avery, Oswald T.
author_sort Heidelberger, Michael
collection PubMed
description 1. The method for the concentration and purification of the soluble specific substance of Pneumococcus has been improved. 2. Highly purified specific substance of Type II pneumococcus of polysaccharide nature is shown to be recovered essentially unchanged after precipitation by immune serum, by uranyl nitrate, by basic lead acetate, or by safranine. 3. Marked chemical differences are shown to exist between the specific substances of Type II and Type III pneumococcus, although both react as polysaccharides. 4. The weight of evidence is considered to be in favor of the view that the specific substances of Pneumococcus Types II and III are actually polysaccharide derivatives. 5. The immunological significance of the foregoing view is discussed.
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spelling pubmed-21285762008-04-18 THE SOLUBLE SPECIFIC SUBSTANCE OF PNEUMOCOCCUS : SECOND PAPER. Heidelberger, Michael Avery, Oswald T. J Exp Med Article 1. The method for the concentration and purification of the soluble specific substance of Pneumococcus has been improved. 2. Highly purified specific substance of Type II pneumococcus of polysaccharide nature is shown to be recovered essentially unchanged after precipitation by immune serum, by uranyl nitrate, by basic lead acetate, or by safranine. 3. Marked chemical differences are shown to exist between the specific substances of Type II and Type III pneumococcus, although both react as polysaccharides. 4. The weight of evidence is considered to be in favor of the view that the specific substances of Pneumococcus Types II and III are actually polysaccharide derivatives. 5. The immunological significance of the foregoing view is discussed. The Rockefeller University Press 1924-08-31 /pmc/articles/PMC2128576/ /pubmed/19868919 Text en Copyright © Copyright, 1924, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Heidelberger, Michael
Avery, Oswald T.
THE SOLUBLE SPECIFIC SUBSTANCE OF PNEUMOCOCCUS : SECOND PAPER.
title THE SOLUBLE SPECIFIC SUBSTANCE OF PNEUMOCOCCUS : SECOND PAPER.
title_full THE SOLUBLE SPECIFIC SUBSTANCE OF PNEUMOCOCCUS : SECOND PAPER.
title_fullStr THE SOLUBLE SPECIFIC SUBSTANCE OF PNEUMOCOCCUS : SECOND PAPER.
title_full_unstemmed THE SOLUBLE SPECIFIC SUBSTANCE OF PNEUMOCOCCUS : SECOND PAPER.
title_short THE SOLUBLE SPECIFIC SUBSTANCE OF PNEUMOCOCCUS : SECOND PAPER.
title_sort soluble specific substance of pneumococcus : second paper.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2128576/
https://www.ncbi.nlm.nih.gov/pubmed/19868919
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