GROWTH OF FIBROBLASTS AND HYDROGEN ION CONCENTRATION OF THE MEDIUM

1. The rate of growth of fibroblasts is markedly modified by slight changes in the hydrogen ion concentration of the medium. The curves expressing the rate of growth in function of the hydrogen ion concentration of the medium are nearly symmetrical on both sides of the maximum. 2. The optimum growth...

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Detalles Bibliográficos
Autor principal: Fischer, Albert
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1921
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2128691/
https://www.ncbi.nlm.nih.gov/pubmed/19868570
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author Fischer, Albert
author_facet Fischer, Albert
author_sort Fischer, Albert
collection PubMed
description 1. The rate of growth of fibroblasts is markedly modified by slight changes in the hydrogen ion concentration of the medium. The curves expressing the rate of growth in function of the hydrogen ion concentration of the medium are nearly symmetrical on both sides of the maximum. 2. The optimum growth of fibroblasts occurs at pH 7.4 to 7.8. A slight change from this reaction has a remarkable influence on the rate of growth. 3. Fibroblasts show more resistance to higher alkalinity than to higher acidity. They grew for only four to six generations in a medium having a pH of 5.5, and for more than ten generations in one of 8.5. 4. The influence of different hydrogen ion concentrations on fibroblasts was only of a quantitative nature.
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spelling pubmed-21286912008-04-18 GROWTH OF FIBROBLASTS AND HYDROGEN ION CONCENTRATION OF THE MEDIUM Fischer, Albert J Exp Med Article 1. The rate of growth of fibroblasts is markedly modified by slight changes in the hydrogen ion concentration of the medium. The curves expressing the rate of growth in function of the hydrogen ion concentration of the medium are nearly symmetrical on both sides of the maximum. 2. The optimum growth of fibroblasts occurs at pH 7.4 to 7.8. A slight change from this reaction has a remarkable influence on the rate of growth. 3. Fibroblasts show more resistance to higher alkalinity than to higher acidity. They grew for only four to six generations in a medium having a pH of 5.5, and for more than ten generations in one of 8.5. 4. The influence of different hydrogen ion concentrations on fibroblasts was only of a quantitative nature. The Rockefeller University Press 1921-10-31 /pmc/articles/PMC2128691/ /pubmed/19868570 Text en Copyright © Copyright, 1921, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Fischer, Albert
GROWTH OF FIBROBLASTS AND HYDROGEN ION CONCENTRATION OF THE MEDIUM
title GROWTH OF FIBROBLASTS AND HYDROGEN ION CONCENTRATION OF THE MEDIUM
title_full GROWTH OF FIBROBLASTS AND HYDROGEN ION CONCENTRATION OF THE MEDIUM
title_fullStr GROWTH OF FIBROBLASTS AND HYDROGEN ION CONCENTRATION OF THE MEDIUM
title_full_unstemmed GROWTH OF FIBROBLASTS AND HYDROGEN ION CONCENTRATION OF THE MEDIUM
title_short GROWTH OF FIBROBLASTS AND HYDROGEN ION CONCENTRATION OF THE MEDIUM
title_sort growth of fibroblasts and hydrogen ion concentration of the medium
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2128691/
https://www.ncbi.nlm.nih.gov/pubmed/19868570
work_keys_str_mv AT fischeralbert growthoffibroblastsandhydrogenionconcentrationofthemedium

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