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Effects of a Water-Soluble Cinnamon Extract on Body Composition and Features of the Metabolic Syndrome in Pre-Diabetic Men and Women
PURPOSE: The purpose of this study was to determine the effects of supplementation with a water-soluble cinnamon extract (Cinnulin PF(®)) on body composition and features of the metabolic syndrome. METHODS: Twenty-two subjects with prediabetes and the metabolic syndrome (mean ± SD: age, BMI, systoli...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2129164/ https://www.ncbi.nlm.nih.gov/pubmed/18500972 http://dx.doi.org/10.1186/1550-2783-3-2-45 |
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author | Ziegenfuss, Tim N Hofheins, Jennifer E Mendel, Ronald W Landis, Jamie Anderson, Richard A |
author_facet | Ziegenfuss, Tim N Hofheins, Jennifer E Mendel, Ronald W Landis, Jamie Anderson, Richard A |
author_sort | Ziegenfuss, Tim N |
collection | PubMed |
description | PURPOSE: The purpose of this study was to determine the effects of supplementation with a water-soluble cinnamon extract (Cinnulin PF(®)) on body composition and features of the metabolic syndrome. METHODS: Twenty-two subjects with prediabetes and the metabolic syndrome (mean ± SD: age, BMI, systolic blood pressure [SBP], fasting blood glucose [FBG]: 46.0 ± 9.7 y; 33.2 ± 9.3 kg/m(2); 133 ± 17 mm Hg; 114.3 ± 11.6 mg/dL) were randomly assigned to supplement their diet with either Cinnulin PF(® )(500 mg/d) or a placebo for 12-weeks. Main outcome measures were changes in FBG, SBP, and body composition measured after 12-weeks of supplementation. The primary statistical analyses consisted of two factor (group × time), repeated-measures ANOVA for between group differences over time. In all analyses, an intent-to-treat approach was used and significance was accepted at P < 0.05. RESULTS: Subjects in the Cinnulin PF(® )group had significant decreases in FBG (-8.4%: 116.3 ± 12.8 mg/dL [pre] to 106.5 ± 20.1 mg/dL [post], p < 0.01), SBP (-3.8%: 133 ± 14 mm Hg [pre] to 128 ± 18 mm Hg [post], p < 0.001), and increases in lean mass (+1.1%: 53.7 ± 11.8 kg [pre] to 54.3 ± 11.8 kg [post], p < 0.002) compared with the placebo group. Additionally, within-group analyses uncovered small, but statistically significant decreases in body fat (-0.7%: 37.9 ± 9.2% [pre] to 37.2 ± 8.9% [post], p < 0.02) in the Cinnulin PF(® )group. No significant changes in clinical blood chemistries were observed between groups over time. CONCLUSION: These data support the efficacy of Cinnulin PF(® )supplementation on reducing FBG and SBP, and improving body composition in men and women with the metabolic syndrome and suggest that this naturally-occurring spice can reduce risk factors associated with diabetes and cardiovascular diseases. |
format | Text |
id | pubmed-2129164 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-21291642007-12-12 Effects of a Water-Soluble Cinnamon Extract on Body Composition and Features of the Metabolic Syndrome in Pre-Diabetic Men and Women Ziegenfuss, Tim N Hofheins, Jennifer E Mendel, Ronald W Landis, Jamie Anderson, Richard A J Int Soc Sports Nutr Research Article PURPOSE: The purpose of this study was to determine the effects of supplementation with a water-soluble cinnamon extract (Cinnulin PF(®)) on body composition and features of the metabolic syndrome. METHODS: Twenty-two subjects with prediabetes and the metabolic syndrome (mean ± SD: age, BMI, systolic blood pressure [SBP], fasting blood glucose [FBG]: 46.0 ± 9.7 y; 33.2 ± 9.3 kg/m(2); 133 ± 17 mm Hg; 114.3 ± 11.6 mg/dL) were randomly assigned to supplement their diet with either Cinnulin PF(® )(500 mg/d) or a placebo for 12-weeks. Main outcome measures were changes in FBG, SBP, and body composition measured after 12-weeks of supplementation. The primary statistical analyses consisted of two factor (group × time), repeated-measures ANOVA for between group differences over time. In all analyses, an intent-to-treat approach was used and significance was accepted at P < 0.05. RESULTS: Subjects in the Cinnulin PF(® )group had significant decreases in FBG (-8.4%: 116.3 ± 12.8 mg/dL [pre] to 106.5 ± 20.1 mg/dL [post], p < 0.01), SBP (-3.8%: 133 ± 14 mm Hg [pre] to 128 ± 18 mm Hg [post], p < 0.001), and increases in lean mass (+1.1%: 53.7 ± 11.8 kg [pre] to 54.3 ± 11.8 kg [post], p < 0.002) compared with the placebo group. Additionally, within-group analyses uncovered small, but statistically significant decreases in body fat (-0.7%: 37.9 ± 9.2% [pre] to 37.2 ± 8.9% [post], p < 0.02) in the Cinnulin PF(® )group. No significant changes in clinical blood chemistries were observed between groups over time. CONCLUSION: These data support the efficacy of Cinnulin PF(® )supplementation on reducing FBG and SBP, and improving body composition in men and women with the metabolic syndrome and suggest that this naturally-occurring spice can reduce risk factors associated with diabetes and cardiovascular diseases. BioMed Central 2006-12-28 /pmc/articles/PMC2129164/ /pubmed/18500972 http://dx.doi.org/10.1186/1550-2783-3-2-45 Text en Copyright © 2006 A National Library of Congress Indexed Journal |
spellingShingle | Research Article Ziegenfuss, Tim N Hofheins, Jennifer E Mendel, Ronald W Landis, Jamie Anderson, Richard A Effects of a Water-Soluble Cinnamon Extract on Body Composition and Features of the Metabolic Syndrome in Pre-Diabetic Men and Women |
title | Effects of a Water-Soluble Cinnamon Extract on Body Composition and Features of the Metabolic Syndrome in Pre-Diabetic Men and Women |
title_full | Effects of a Water-Soluble Cinnamon Extract on Body Composition and Features of the Metabolic Syndrome in Pre-Diabetic Men and Women |
title_fullStr | Effects of a Water-Soluble Cinnamon Extract on Body Composition and Features of the Metabolic Syndrome in Pre-Diabetic Men and Women |
title_full_unstemmed | Effects of a Water-Soluble Cinnamon Extract on Body Composition and Features of the Metabolic Syndrome in Pre-Diabetic Men and Women |
title_short | Effects of a Water-Soluble Cinnamon Extract on Body Composition and Features of the Metabolic Syndrome in Pre-Diabetic Men and Women |
title_sort | effects of a water-soluble cinnamon extract on body composition and features of the metabolic syndrome in pre-diabetic men and women |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2129164/ https://www.ncbi.nlm.nih.gov/pubmed/18500972 http://dx.doi.org/10.1186/1550-2783-3-2-45 |
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