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STUDIES ON THE OXIDATION-REDUCTION OF HEMOGLOBIN AND METHEMOGLOBIN : I. THE CHANGES INDUCED BY PNEUMOCOCCI AND BY STERILE ANIMAL TISSUE.
The Pneumococcus is capable of oxidizing hemoglobin to methemoglobin and of reducing the latter to hemoglobin again. Both the living organism and sterile extracts will accomplish the changes; and like systems seem to be involved in them. The type of reaction induced is determined by the presence or...
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1925
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2130940/ https://www.ncbi.nlm.nih.gov/pubmed/19868989 |
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author | Neill, James M. |
author_facet | Neill, James M. |
author_sort | Neill, James M. |
collection | PubMed |
description | The Pneumococcus is capable of oxidizing hemoglobin to methemoglobin and of reducing the latter to hemoglobin again. Both the living organism and sterile extracts will accomplish the changes; and like systems seem to be involved in them. The type of reaction induced is determined by the presence or absence of molecular oxygen. The oxidation and reduction of the blood pigments are reversible processes. The equilibrium between hemoglobin and methemoglobin in a mixture of blood and pneumococcus cellular substances may be shifted in either direction at will by regulation of the oxygen tension. In the present paper quantitative evidence is presented of the reduction of methemoglobin to hemoglobin by sterile animal tissues. The possible relations of this activity to the disappearance of methemoglobin from the blood stream of the living animal are discussed. |
format | Text |
id | pubmed-2130940 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1925 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21309402008-04-18 STUDIES ON THE OXIDATION-REDUCTION OF HEMOGLOBIN AND METHEMOGLOBIN : I. THE CHANGES INDUCED BY PNEUMOCOCCI AND BY STERILE ANIMAL TISSUE. Neill, James M. J Exp Med Article The Pneumococcus is capable of oxidizing hemoglobin to methemoglobin and of reducing the latter to hemoglobin again. Both the living organism and sterile extracts will accomplish the changes; and like systems seem to be involved in them. The type of reaction induced is determined by the presence or absence of molecular oxygen. The oxidation and reduction of the blood pigments are reversible processes. The equilibrium between hemoglobin and methemoglobin in a mixture of blood and pneumococcus cellular substances may be shifted in either direction at will by regulation of the oxygen tension. In the present paper quantitative evidence is presented of the reduction of methemoglobin to hemoglobin by sterile animal tissues. The possible relations of this activity to the disappearance of methemoglobin from the blood stream of the living animal are discussed. The Rockefeller University Press 1925-01-31 /pmc/articles/PMC2130940/ /pubmed/19868989 Text en Copyright © Copyright, 1925, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Neill, James M. STUDIES ON THE OXIDATION-REDUCTION OF HEMOGLOBIN AND METHEMOGLOBIN : I. THE CHANGES INDUCED BY PNEUMOCOCCI AND BY STERILE ANIMAL TISSUE. |
title | STUDIES ON THE OXIDATION-REDUCTION OF HEMOGLOBIN AND METHEMOGLOBIN : I. THE CHANGES INDUCED BY PNEUMOCOCCI AND BY STERILE ANIMAL TISSUE. |
title_full | STUDIES ON THE OXIDATION-REDUCTION OF HEMOGLOBIN AND METHEMOGLOBIN : I. THE CHANGES INDUCED BY PNEUMOCOCCI AND BY STERILE ANIMAL TISSUE. |
title_fullStr | STUDIES ON THE OXIDATION-REDUCTION OF HEMOGLOBIN AND METHEMOGLOBIN : I. THE CHANGES INDUCED BY PNEUMOCOCCI AND BY STERILE ANIMAL TISSUE. |
title_full_unstemmed | STUDIES ON THE OXIDATION-REDUCTION OF HEMOGLOBIN AND METHEMOGLOBIN : I. THE CHANGES INDUCED BY PNEUMOCOCCI AND BY STERILE ANIMAL TISSUE. |
title_short | STUDIES ON THE OXIDATION-REDUCTION OF HEMOGLOBIN AND METHEMOGLOBIN : I. THE CHANGES INDUCED BY PNEUMOCOCCI AND BY STERILE ANIMAL TISSUE. |
title_sort | studies on the oxidation-reduction of hemoglobin and methemoglobin : i. the changes induced by pneumococci and by sterile animal tissue. |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2130940/ https://www.ncbi.nlm.nih.gov/pubmed/19868989 |
work_keys_str_mv | AT neilljamesm studiesontheoxidationreductionofhemoglobinandmethemoglobinithechangesinducedbypneumococciandbysterileanimaltissue |