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ON THE ANTIGENS OF RED BLOOD CORPUSCLES : THE QUESTION OF LIPOID ANTIGENS.
Erythrocytes contain more than one substance responsible for the production of lysins and agglutinins. By injections of alcoholic extracts of horse erythrocytes mixed with a foreign serum, hemolysins and agglutinins can be more readily obtained than by the same quantities of extract alone. The immun...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
1925
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2130953/ https://www.ncbi.nlm.nih.gov/pubmed/19868998 |
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author | Landsteiner, K. van der Scheer, James |
author_facet | Landsteiner, K. van der Scheer, James |
author_sort | Landsteiner, K. |
collection | PubMed |
description | Erythrocytes contain more than one substance responsible for the production of lysins and agglutinins. By injections of alcoholic extracts of horse erythrocytes mixed with a foreign serum, hemolysins and agglutinins can be more readily obtained than by the same quantities of extract alone. The immune sera reacted on horse and donkey blood but not on the blood of other species. The antibodies obtained differ from those prepared in the usual way with unchanged red blood corpuscles. The differences involve the ratio lysin: agglutinin, the specificity, the inhibition of hemolysis by alcoholic extracts, and the flocculation of these extracts. Ordinary anti-horse sera give flocculation reactions with emulsions of alcoholic extracts of corpuscles but to a lesser degree and not so regularly as those produced by means of extracts. The specific substances present in alcoholic blood extracts are probably not proteins. According to this view, species specificity in animals depends not alone on proteins but also on another group of substances. |
format | Text |
id | pubmed-2130953 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1925 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21309532008-04-18 ON THE ANTIGENS OF RED BLOOD CORPUSCLES : THE QUESTION OF LIPOID ANTIGENS. Landsteiner, K. van der Scheer, James J Exp Med Article Erythrocytes contain more than one substance responsible for the production of lysins and agglutinins. By injections of alcoholic extracts of horse erythrocytes mixed with a foreign serum, hemolysins and agglutinins can be more readily obtained than by the same quantities of extract alone. The immune sera reacted on horse and donkey blood but not on the blood of other species. The antibodies obtained differ from those prepared in the usual way with unchanged red blood corpuscles. The differences involve the ratio lysin: agglutinin, the specificity, the inhibition of hemolysis by alcoholic extracts, and the flocculation of these extracts. Ordinary anti-horse sera give flocculation reactions with emulsions of alcoholic extracts of corpuscles but to a lesser degree and not so regularly as those produced by means of extracts. The specific substances present in alcoholic blood extracts are probably not proteins. According to this view, species specificity in animals depends not alone on proteins but also on another group of substances. The Rockefeller University Press 1925-02-28 /pmc/articles/PMC2130953/ /pubmed/19868998 Text en Copyright © Copyright, 1925, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Landsteiner, K. van der Scheer, James ON THE ANTIGENS OF RED BLOOD CORPUSCLES : THE QUESTION OF LIPOID ANTIGENS. |
title | ON THE ANTIGENS OF RED BLOOD CORPUSCLES : THE QUESTION OF LIPOID ANTIGENS. |
title_full | ON THE ANTIGENS OF RED BLOOD CORPUSCLES : THE QUESTION OF LIPOID ANTIGENS. |
title_fullStr | ON THE ANTIGENS OF RED BLOOD CORPUSCLES : THE QUESTION OF LIPOID ANTIGENS. |
title_full_unstemmed | ON THE ANTIGENS OF RED BLOOD CORPUSCLES : THE QUESTION OF LIPOID ANTIGENS. |
title_short | ON THE ANTIGENS OF RED BLOOD CORPUSCLES : THE QUESTION OF LIPOID ANTIGENS. |
title_sort | on the antigens of red blood corpuscles : the question of lipoid antigens. |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2130953/ https://www.ncbi.nlm.nih.gov/pubmed/19868998 |
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