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VARIATIONS IN SPECIFICITY AND VIRULENCE OF PNEUMOCOCCI DURING GROWTH IN VITRO

When pneumococci are grown repeatedly in broth containing immune serum or bile, they become less virulent and less type-specific. These changes are apparently due to the fact that under the conditions mentioned a number of organisms appear which have lost certain properties. These variant organisms...

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Detalles Bibliográficos
Autor principal: Reimann, Hobart A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1925
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2130974/
https://www.ncbi.nlm.nih.gov/pubmed/19869011
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author Reimann, Hobart A.
author_facet Reimann, Hobart A.
author_sort Reimann, Hobart A.
collection PubMed
description When pneumococci are grown repeatedly in broth containing immune serum or bile, they become less virulent and less type-specific. These changes are apparently due to the fact that under the conditions mentioned a number of organisms appear which have lost certain properties. These variant organisms form colonies differing in appearance from the colonies of the typical organisms, and cultures made from the atypical colonies are avirulent and are not type-specific, The degree of modification of the original culture is directly related to the relative number of organisms that have undergone variation. After prolonged growth in bile or homologous immune serum variation may have become manifest in all the bacteria of the cultures and the change is then irreversible. The significance of these findings as regards the epidemiology of pneumococcus infections is noted.
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spelling pubmed-21309742008-04-18 VARIATIONS IN SPECIFICITY AND VIRULENCE OF PNEUMOCOCCI DURING GROWTH IN VITRO Reimann, Hobart A. J Exp Med Article When pneumococci are grown repeatedly in broth containing immune serum or bile, they become less virulent and less type-specific. These changes are apparently due to the fact that under the conditions mentioned a number of organisms appear which have lost certain properties. These variant organisms form colonies differing in appearance from the colonies of the typical organisms, and cultures made from the atypical colonies are avirulent and are not type-specific, The degree of modification of the original culture is directly related to the relative number of organisms that have undergone variation. After prolonged growth in bile or homologous immune serum variation may have become manifest in all the bacteria of the cultures and the change is then irreversible. The significance of these findings as regards the epidemiology of pneumococcus infections is noted. The Rockefeller University Press 1925-04-30 /pmc/articles/PMC2130974/ /pubmed/19869011 Text en Copyright © Copyright, 1925, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Reimann, Hobart A.
VARIATIONS IN SPECIFICITY AND VIRULENCE OF PNEUMOCOCCI DURING GROWTH IN VITRO
title VARIATIONS IN SPECIFICITY AND VIRULENCE OF PNEUMOCOCCI DURING GROWTH IN VITRO
title_full VARIATIONS IN SPECIFICITY AND VIRULENCE OF PNEUMOCOCCI DURING GROWTH IN VITRO
title_fullStr VARIATIONS IN SPECIFICITY AND VIRULENCE OF PNEUMOCOCCI DURING GROWTH IN VITRO
title_full_unstemmed VARIATIONS IN SPECIFICITY AND VIRULENCE OF PNEUMOCOCCI DURING GROWTH IN VITRO
title_short VARIATIONS IN SPECIFICITY AND VIRULENCE OF PNEUMOCOCCI DURING GROWTH IN VITRO
title_sort variations in specificity and virulence of pneumococci during growth in vitro
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2130974/
https://www.ncbi.nlm.nih.gov/pubmed/19869011
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