EFFECT OF PREPUBERTY CASTRATION ON SUBSEQUENT CANCER IMPLANTATION

Male and female mice castrated during the first 7 weeks of life and implanted with cancer at later periods show a resistance definitely higher than do intact animals of the same age. This increased refractiveness is evident at 3 months after the operation but is more pronounced at 8 months to a year...

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Detalles Bibliográficos
Autores principales: Murphy, James B., Sturm, Ernest
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1925
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2131001/
https://www.ncbi.nlm.nih.gov/pubmed/19869042
Descripción
Sumario:Male and female mice castrated during the first 7 weeks of life and implanted with cancer at later periods show a resistance definitely higher than do intact animals of the same age. This increased refractiveness is evident at 3 months after the operation but is more pronounced at 8 months to a year. Even castration in early adult life seems to increase the refractory state to later cancer inoculation. On the other hand, adult mice inoculated within a week after castration show slight if any evidence of increased resistance.

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