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STUDIES ON THE BACTERIOPHAGE OF D'HERELLE : V. EFFECT OF ELECTROLYTES ON THE RATE OF INACTIVATION OF BACTERIOPHAGE BY ALCOHOL.
Addition of neutral salts to the lytic filtrate results in an increased rate of inactivation of the latter when alcohol is added to it. This effect of salts is the more marked the higher the valency of the cation. Conversely, removal by dialysis of salts originally present in the lytic filtrate tend...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1926
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2131099/ https://www.ncbi.nlm.nih.gov/pubmed/19869107 |
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author | Bronfenbrenner, Jacques J. Korb, Charles |
author_facet | Bronfenbrenner, Jacques J. Korb, Charles |
author_sort | Bronfenbrenner, Jacques J. |
collection | PubMed |
description | Addition of neutral salts to the lytic filtrate results in an increased rate of inactivation of the latter when alcohol is added to it. This effect of salts is the more marked the higher the valency of the cation. Conversely, removal by dialysis of salts originally present in the lytic filtrate tends to render lytic agent less sensitive to alcohol. Restitution of the original salt content to the dialyzed filtrate tends to bring the sensitiveness to alcohol in the dialyzed filtrate to the level of the non-dialyzed control. It appears, therefore, that inactivation of the lytic agent by alcohol depends directly on the rate of precipitation of the coagulable constituents of the medium, and is not the result of a direct toxic action of alcohol on "bacteriophagum intestinale." Considered in association with our earlier findings, these results speak in favor of the chemical nature of the agent of transmissible lysis. |
format | Text |
id | pubmed-2131099 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1926 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21310992008-04-18 STUDIES ON THE BACTERIOPHAGE OF D'HERELLE : V. EFFECT OF ELECTROLYTES ON THE RATE OF INACTIVATION OF BACTERIOPHAGE BY ALCOHOL. Bronfenbrenner, Jacques J. Korb, Charles J Exp Med Article Addition of neutral salts to the lytic filtrate results in an increased rate of inactivation of the latter when alcohol is added to it. This effect of salts is the more marked the higher the valency of the cation. Conversely, removal by dialysis of salts originally present in the lytic filtrate tends to render lytic agent less sensitive to alcohol. Restitution of the original salt content to the dialyzed filtrate tends to bring the sensitiveness to alcohol in the dialyzed filtrate to the level of the non-dialyzed control. It appears, therefore, that inactivation of the lytic agent by alcohol depends directly on the rate of precipitation of the coagulable constituents of the medium, and is not the result of a direct toxic action of alcohol on "bacteriophagum intestinale." Considered in association with our earlier findings, these results speak in favor of the chemical nature of the agent of transmissible lysis. The Rockefeller University Press 1926-01-01 /pmc/articles/PMC2131099/ /pubmed/19869107 Text en Copyright © Copyright, 1926, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Bronfenbrenner, Jacques J. Korb, Charles STUDIES ON THE BACTERIOPHAGE OF D'HERELLE : V. EFFECT OF ELECTROLYTES ON THE RATE OF INACTIVATION OF BACTERIOPHAGE BY ALCOHOL. |
title | STUDIES ON THE BACTERIOPHAGE OF D'HERELLE : V. EFFECT OF ELECTROLYTES ON THE RATE OF INACTIVATION OF BACTERIOPHAGE BY ALCOHOL. |
title_full | STUDIES ON THE BACTERIOPHAGE OF D'HERELLE : V. EFFECT OF ELECTROLYTES ON THE RATE OF INACTIVATION OF BACTERIOPHAGE BY ALCOHOL. |
title_fullStr | STUDIES ON THE BACTERIOPHAGE OF D'HERELLE : V. EFFECT OF ELECTROLYTES ON THE RATE OF INACTIVATION OF BACTERIOPHAGE BY ALCOHOL. |
title_full_unstemmed | STUDIES ON THE BACTERIOPHAGE OF D'HERELLE : V. EFFECT OF ELECTROLYTES ON THE RATE OF INACTIVATION OF BACTERIOPHAGE BY ALCOHOL. |
title_short | STUDIES ON THE BACTERIOPHAGE OF D'HERELLE : V. EFFECT OF ELECTROLYTES ON THE RATE OF INACTIVATION OF BACTERIOPHAGE BY ALCOHOL. |
title_sort | studies on the bacteriophage of d'herelle : v. effect of electrolytes on the rate of inactivation of bacteriophage by alcohol. |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2131099/ https://www.ncbi.nlm.nih.gov/pubmed/19869107 |
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