STUDIES ON THE OXIDATION AND REDUCTION OF IMMUNOLOGICAL SUBSTANCES : VI. THE "REACTIVATION" OF THE BACTERIOLYTIC ACTIVITY OF OXIDIZED PNEUMOCOCCUS EXTRACTS.

The methods previously employed in the study of hemotoxins have been applied in the present investigation to the oxidation and reduction of the bacteriolytic substance of Pneumococcus. It is shown that the bacteriolytic agent, previously inactivated by oxidation, can be "reactivated" by tr...

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Detalles Bibliográficos
Autores principales: Neill, James M., Fleming, William L.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1927
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2131174/
https://www.ncbi.nlm.nih.gov/pubmed/19869337
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author Neill, James M.
Fleming, William L.
author_facet Neill, James M.
Fleming, William L.
author_sort Neill, James M.
collection PubMed
description The methods previously employed in the study of hemotoxins have been applied in the present investigation to the oxidation and reduction of the bacteriolytic substance of Pneumococcus. It is shown that the bacteriolytic agent, previously inactivated by oxidation, can be "reactivated" by treatment with bacterial reducing agents. Evidence is presented that this "reactivation" represents the reduction of inactive, reversible oxidation products to the original active substance. The bacteriolytic agent is an integral constituent of the pneumococcus cell, which can be separated from the hemotoxin by absorption with red blood cells in the cold.
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spelling pubmed-21311742008-04-18 STUDIES ON THE OXIDATION AND REDUCTION OF IMMUNOLOGICAL SUBSTANCES : VI. THE "REACTIVATION" OF THE BACTERIOLYTIC ACTIVITY OF OXIDIZED PNEUMOCOCCUS EXTRACTS. Neill, James M. Fleming, William L. J Exp Med Article The methods previously employed in the study of hemotoxins have been applied in the present investigation to the oxidation and reduction of the bacteriolytic substance of Pneumococcus. It is shown that the bacteriolytic agent, previously inactivated by oxidation, can be "reactivated" by treatment with bacterial reducing agents. Evidence is presented that this "reactivation" represents the reduction of inactive, reversible oxidation products to the original active substance. The bacteriolytic agent is an integral constituent of the pneumococcus cell, which can be separated from the hemotoxin by absorption with red blood cells in the cold. The Rockefeller University Press 1927-07-31 /pmc/articles/PMC2131174/ /pubmed/19869337 Text en Copyright © Copyright, 1927, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Neill, James M.
Fleming, William L.
STUDIES ON THE OXIDATION AND REDUCTION OF IMMUNOLOGICAL SUBSTANCES : VI. THE "REACTIVATION" OF THE BACTERIOLYTIC ACTIVITY OF OXIDIZED PNEUMOCOCCUS EXTRACTS.
title STUDIES ON THE OXIDATION AND REDUCTION OF IMMUNOLOGICAL SUBSTANCES : VI. THE "REACTIVATION" OF THE BACTERIOLYTIC ACTIVITY OF OXIDIZED PNEUMOCOCCUS EXTRACTS.
title_full STUDIES ON THE OXIDATION AND REDUCTION OF IMMUNOLOGICAL SUBSTANCES : VI. THE "REACTIVATION" OF THE BACTERIOLYTIC ACTIVITY OF OXIDIZED PNEUMOCOCCUS EXTRACTS.
title_fullStr STUDIES ON THE OXIDATION AND REDUCTION OF IMMUNOLOGICAL SUBSTANCES : VI. THE "REACTIVATION" OF THE BACTERIOLYTIC ACTIVITY OF OXIDIZED PNEUMOCOCCUS EXTRACTS.
title_full_unstemmed STUDIES ON THE OXIDATION AND REDUCTION OF IMMUNOLOGICAL SUBSTANCES : VI. THE "REACTIVATION" OF THE BACTERIOLYTIC ACTIVITY OF OXIDIZED PNEUMOCOCCUS EXTRACTS.
title_short STUDIES ON THE OXIDATION AND REDUCTION OF IMMUNOLOGICAL SUBSTANCES : VI. THE "REACTIVATION" OF THE BACTERIOLYTIC ACTIVITY OF OXIDIZED PNEUMOCOCCUS EXTRACTS.
title_sort studies on the oxidation and reduction of immunological substances : vi. the "reactivation" of the bacteriolytic activity of oxidized pneumococcus extracts.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2131174/
https://www.ncbi.nlm.nih.gov/pubmed/19869337
work_keys_str_mv AT neilljamesm studiesontheoxidationandreductionofimmunologicalsubstancesvithereactivationofthebacteriolyticactivityofoxidizedpneumococcusextracts
AT flemingwilliaml studiesontheoxidationandreductionofimmunologicalsubstancesvithereactivationofthebacteriolyticactivityofoxidizedpneumococcusextracts

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