THE INFLUENCE OF THYROIDECTOMY, SPLENECTOMY, GONADECTOMY, AND SUPRARENALECTOMY UPON THE DEVELOPMENT OF EXPERIMENTAL ATHEROSCLEROSIS IN RABBITS

Alimentary hypercholesterolemia acting over a sufficient period of time (in rabbits with all organs intact, 110 days or longer) causes deposition of cholesterol within the intima of the aorta. Deposition of cholesterol within the intima of the aorta initiates the formation of experimental atheromata...

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Detalles Bibliográficos
Autor principal: Shapiro, Shepard
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1927
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2131217/
https://www.ncbi.nlm.nih.gov/pubmed/19869275
Descripción
Sumario:Alimentary hypercholesterolemia acting over a sufficient period of time (in rabbits with all organs intact, 110 days or longer) causes deposition of cholesterol within the intima of the aorta. Deposition of cholesterol within the intima of the aorta initiates the formation of experimental atheromata. Thyroidectomy, splenectomy, and gonadectomy augment hypercholesterolemia and thereby facilitate and accelerate the development of experimental atheromata of the aorta in rabbits. Sublethal suprarenal insufficiency does not increase the susceptibility of rabbits to the development of such atheromata.

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