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FACTORS INVOLVED IN THE INFECTION OF MICE AFTER VACCINATION WITH TYPE II PNEUMOCOCCI
A group of mice was vaccinated against Type II pneumoccci and subsequently tested for immunity against different numbers of the live bacteria. The immunity tests were conducted within two zones of dosage. In the first zone where the doses were kept within reasonable limits (10(–6) to 10(–3) cc. of c...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
1927
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2131254/ https://www.ncbi.nlm.nih.gov/pubmed/19869317 |
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author | Neill, James M. Gaspari, Emidio L. |
author_facet | Neill, James M. Gaspari, Emidio L. |
author_sort | Neill, James M. |
collection | PubMed |
description | A group of mice was vaccinated against Type II pneumoccci and subsequently tested for immunity against different numbers of the live bacteria. The immunity tests were conducted within two zones of dosage. In the first zone where the doses were kept within reasonable limits (10(–6) to 10(–3) cc. of culture), the number of invading bacteria was without influence and the occurrence of infections was determined by the previous immunity response of the individual. In the second zone of dosage (where passive protection also fails), these relations were reversed, and invasion by overwhelming numbers of the bacteria invariably produced infection regardless of the previous immunity response of the individual. These results present an extreme example of the importance of the immunity response of the individual as a factor always concerned in the effectiveness of vaccination. |
format | Text |
id | pubmed-2131254 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1927 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21312542008-04-18 FACTORS INVOLVED IN THE INFECTION OF MICE AFTER VACCINATION WITH TYPE II PNEUMOCOCCI Neill, James M. Gaspari, Emidio L. J Exp Med Article A group of mice was vaccinated against Type II pneumoccci and subsequently tested for immunity against different numbers of the live bacteria. The immunity tests were conducted within two zones of dosage. In the first zone where the doses were kept within reasonable limits (10(–6) to 10(–3) cc. of culture), the number of invading bacteria was without influence and the occurrence of infections was determined by the previous immunity response of the individual. In the second zone of dosage (where passive protection also fails), these relations were reversed, and invasion by overwhelming numbers of the bacteria invariably produced infection regardless of the previous immunity response of the individual. These results present an extreme example of the importance of the immunity response of the individual as a factor always concerned in the effectiveness of vaccination. The Rockefeller University Press 1927-06-30 /pmc/articles/PMC2131254/ /pubmed/19869317 Text en Copyright © Copyright, 1927, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Neill, James M. Gaspari, Emidio L. FACTORS INVOLVED IN THE INFECTION OF MICE AFTER VACCINATION WITH TYPE II PNEUMOCOCCI |
title | FACTORS INVOLVED IN THE INFECTION OF MICE AFTER VACCINATION WITH TYPE II PNEUMOCOCCI |
title_full | FACTORS INVOLVED IN THE INFECTION OF MICE AFTER VACCINATION WITH TYPE II PNEUMOCOCCI |
title_fullStr | FACTORS INVOLVED IN THE INFECTION OF MICE AFTER VACCINATION WITH TYPE II PNEUMOCOCCI |
title_full_unstemmed | FACTORS INVOLVED IN THE INFECTION OF MICE AFTER VACCINATION WITH TYPE II PNEUMOCOCCI |
title_short | FACTORS INVOLVED IN THE INFECTION OF MICE AFTER VACCINATION WITH TYPE II PNEUMOCOCCI |
title_sort | factors involved in the infection of mice after vaccination with type ii pneumococci |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2131254/ https://www.ncbi.nlm.nih.gov/pubmed/19869317 |
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