Cargando…
STUDIES ON PATHOGENIC B. COLI FROM BOVINE SOURCES : I. THE PATHOGENIC ACTION OF CULTURE FILTRATES.
The relatively young bouillon filtrates, 24 and 48 hours old, of certain strains of B. coli obtained directly from the ileum of scouring calves, were highly toxic for calves about 1 month old, as well as for older calves and cows when given into a vein. The symptoms, of panting followed by dyspneic...
Autores principales: | , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
1927
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2131266/ https://www.ncbi.nlm.nih.gov/pubmed/19869318 |
_version_ | 1782142203780399104 |
---|---|
author | Smith, Theobald Little, Ralph B. |
author_facet | Smith, Theobald Little, Ralph B. |
author_sort | Smith, Theobald |
collection | PubMed |
description | The relatively young bouillon filtrates, 24 and 48 hours old, of certain strains of B. coli obtained directly from the ileum of scouring calves, were highly toxic for calves about 1 month old, as well as for older calves and cows when given into a vein. The symptoms, of panting followed by dyspneic and jerky respiration, indicate some at first obstructive action upon the alveolar and endothelial cells, followed by a greater permeability and eventual filling up of the air spaces with a serous, fibrinous, and hemorrhagic exudate. Similar effects are produced in other organs, such as liver and kidneys, if the toxin reaches them or is formed there by multiplying bacteria. There are no immediate or remote effects resembling those on calves following the intraperitoneal or the intracardiac injection of B. coli filtrates into guinea pigs even when the dose represents many multiples, per body weight, of the dangerous or even fatal calf dose. The administration of the filtrate subcutaneously is without visible effect. Similarly, feeding large numbers of living bacilli produced no manifest disturbances. In support of the hypothesis of a genetic relation between the group of B. coli and of paratyphoid, a similar but less severe effect was produced in a calf by the intravenous injection of a bouillon filtrate of a paratyphoid strain. |
format | Text |
id | pubmed-2131266 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1927 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21312662008-04-18 STUDIES ON PATHOGENIC B. COLI FROM BOVINE SOURCES : I. THE PATHOGENIC ACTION OF CULTURE FILTRATES. Smith, Theobald Little, Ralph B. J Exp Med Article The relatively young bouillon filtrates, 24 and 48 hours old, of certain strains of B. coli obtained directly from the ileum of scouring calves, were highly toxic for calves about 1 month old, as well as for older calves and cows when given into a vein. The symptoms, of panting followed by dyspneic and jerky respiration, indicate some at first obstructive action upon the alveolar and endothelial cells, followed by a greater permeability and eventual filling up of the air spaces with a serous, fibrinous, and hemorrhagic exudate. Similar effects are produced in other organs, such as liver and kidneys, if the toxin reaches them or is formed there by multiplying bacteria. There are no immediate or remote effects resembling those on calves following the intraperitoneal or the intracardiac injection of B. coli filtrates into guinea pigs even when the dose represents many multiples, per body weight, of the dangerous or even fatal calf dose. The administration of the filtrate subcutaneously is without visible effect. Similarly, feeding large numbers of living bacilli produced no manifest disturbances. In support of the hypothesis of a genetic relation between the group of B. coli and of paratyphoid, a similar but less severe effect was produced in a calf by the intravenous injection of a bouillon filtrate of a paratyphoid strain. The Rockefeller University Press 1927-06-30 /pmc/articles/PMC2131266/ /pubmed/19869318 Text en Copyright © Copyright, 1927, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Smith, Theobald Little, Ralph B. STUDIES ON PATHOGENIC B. COLI FROM BOVINE SOURCES : I. THE PATHOGENIC ACTION OF CULTURE FILTRATES. |
title | STUDIES ON PATHOGENIC B. COLI FROM BOVINE SOURCES : I. THE PATHOGENIC ACTION OF CULTURE FILTRATES. |
title_full | STUDIES ON PATHOGENIC B. COLI FROM BOVINE SOURCES : I. THE PATHOGENIC ACTION OF CULTURE FILTRATES. |
title_fullStr | STUDIES ON PATHOGENIC B. COLI FROM BOVINE SOURCES : I. THE PATHOGENIC ACTION OF CULTURE FILTRATES. |
title_full_unstemmed | STUDIES ON PATHOGENIC B. COLI FROM BOVINE SOURCES : I. THE PATHOGENIC ACTION OF CULTURE FILTRATES. |
title_short | STUDIES ON PATHOGENIC B. COLI FROM BOVINE SOURCES : I. THE PATHOGENIC ACTION OF CULTURE FILTRATES. |
title_sort | studies on pathogenic b. coli from bovine sources : i. the pathogenic action of culture filtrates. |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2131266/ https://www.ncbi.nlm.nih.gov/pubmed/19869318 |
work_keys_str_mv | AT smiththeobald studiesonpathogenicbcolifrombovinesourcesithepathogenicactionofculturefiltrates AT littleralphb studiesonpathogenicbcolifrombovinesourcesithepathogenicactionofculturefiltrates |