THE RÔLE OF THE RETICULO-ENDOTHELIAL SYSTEM IN IMMUNITY : IV. THE ACTION OF DIPHTHERIA TOXIN IN SPLENECTOMIZED AND BLOCKED MICE.

1. The minimum amount of diphtheria toxin which killed normal mice of from 24 to 30 gm. in weight upon intravenous injection, was found to be between 75 and 100 times the M.F.D. for the guinea pig. When given intraperitoneally, the fatal dose for mice was as high as 200 M.F.D. 2. There was no signif...

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Detalles Bibliográficos
Autor principal: Jungeblut, C. W.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1927
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2131306/
https://www.ncbi.nlm.nih.gov/pubmed/19869360
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author Jungeblut, C. W.
author_facet Jungeblut, C. W.
author_sort Jungeblut, C. W.
collection PubMed
description 1. The minimum amount of diphtheria toxin which killed normal mice of from 24 to 30 gm. in weight upon intravenous injection, was found to be between 75 and 100 times the M.F.D. for the guinea pig. When given intraperitoneally, the fatal dose for mice was as high as 200 M.F.D. 2. There was no significant difference in the lethal action of diphtheria toxin for normal mice and mice in which an elimination of the reticulo-endothelial system had been attempted by means of blocking injections of India ink, or splenectomy, or a combination of both operations. 3. Attempts to infect normal mice and mice treated as described with large doses of a highly virulent diphtheria strain were unsuccessful with both groups of animals.
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spelling pubmed-21313062008-04-18 THE RÔLE OF THE RETICULO-ENDOTHELIAL SYSTEM IN IMMUNITY : IV. THE ACTION OF DIPHTHERIA TOXIN IN SPLENECTOMIZED AND BLOCKED MICE. Jungeblut, C. W. J Exp Med Article 1. The minimum amount of diphtheria toxin which killed normal mice of from 24 to 30 gm. in weight upon intravenous injection, was found to be between 75 and 100 times the M.F.D. for the guinea pig. When given intraperitoneally, the fatal dose for mice was as high as 200 M.F.D. 2. There was no significant difference in the lethal action of diphtheria toxin for normal mice and mice in which an elimination of the reticulo-endothelial system had been attempted by means of blocking injections of India ink, or splenectomy, or a combination of both operations. 3. Attempts to infect normal mice and mice treated as described with large doses of a highly virulent diphtheria strain were unsuccessful with both groups of animals. The Rockefeller University Press 1927-09-30 /pmc/articles/PMC2131306/ /pubmed/19869360 Text en Copyright © Copyright, 1927, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Jungeblut, C. W.
THE RÔLE OF THE RETICULO-ENDOTHELIAL SYSTEM IN IMMUNITY : IV. THE ACTION OF DIPHTHERIA TOXIN IN SPLENECTOMIZED AND BLOCKED MICE.
title THE RÔLE OF THE RETICULO-ENDOTHELIAL SYSTEM IN IMMUNITY : IV. THE ACTION OF DIPHTHERIA TOXIN IN SPLENECTOMIZED AND BLOCKED MICE.
title_full THE RÔLE OF THE RETICULO-ENDOTHELIAL SYSTEM IN IMMUNITY : IV. THE ACTION OF DIPHTHERIA TOXIN IN SPLENECTOMIZED AND BLOCKED MICE.
title_fullStr THE RÔLE OF THE RETICULO-ENDOTHELIAL SYSTEM IN IMMUNITY : IV. THE ACTION OF DIPHTHERIA TOXIN IN SPLENECTOMIZED AND BLOCKED MICE.
title_full_unstemmed THE RÔLE OF THE RETICULO-ENDOTHELIAL SYSTEM IN IMMUNITY : IV. THE ACTION OF DIPHTHERIA TOXIN IN SPLENECTOMIZED AND BLOCKED MICE.
title_short THE RÔLE OF THE RETICULO-ENDOTHELIAL SYSTEM IN IMMUNITY : IV. THE ACTION OF DIPHTHERIA TOXIN IN SPLENECTOMIZED AND BLOCKED MICE.
title_sort rôle of the reticulo-endothelial system in immunity : iv. the action of diphtheria toxin in splenectomized and blocked mice.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2131306/
https://www.ncbi.nlm.nih.gov/pubmed/19869360
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