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THE RELATION OF MONOCYTES AND CLASMATOCYTES TO EARLY INFECTION IN RABBITS WITH BOVINE TUBERCLE BACILLI

1. The early reaction to intravenous tubercular infection in the various organs of the rabbit reveals a pathognomonic response in the lungs within 24 hours; the specific response in the liver, spleen, lymph glands, and bone marrow, follows from the 6th to the 14th days. 2. The development and extent...

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Autores principales: Sabin, Florence R., Doan, Charles A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1927
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2131307/
https://www.ncbi.nlm.nih.gov/pubmed/19869362
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author Sabin, Florence R.
Doan, Charles A.
author_facet Sabin, Florence R.
Doan, Charles A.
author_sort Sabin, Florence R.
collection PubMed
description 1. The early reaction to intravenous tubercular infection in the various organs of the rabbit reveals a pathognomonic response in the lungs within 24 hours; the specific response in the liver, spleen, lymph glands, and bone marrow, follows from the 6th to the 14th days. 2. The development and extent of the pathologic process has been analyzed in terms of the activity of monocytes and clasmatocytes. 3. The criteria for differentiating these mononuclear phagocytic cells into two strains have been analyzed and the technics discussed. 4. The clasmatocyte phagocytizes tubercle bacilli freely and fragments them, as it does all cellular and other debris. 5. The monocyte stimulated to metamorphose into the typical epithelioid and giant cell of the Langhans type retains the tubercle bacilli intact, with power to survive and multiply, over long periods of time. 6. The normal number of monocytes or the degree to which monoblasts may be stimulated to development and maturation, together with the activity of the clasmatocytes in destroying bacilli, in any particular region, would appear to be a function of the rapidity and extent of the local tubercular involvement.
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spelling pubmed-21313072008-04-18 THE RELATION OF MONOCYTES AND CLASMATOCYTES TO EARLY INFECTION IN RABBITS WITH BOVINE TUBERCLE BACILLI Sabin, Florence R. Doan, Charles A. J Exp Med Article 1. The early reaction to intravenous tubercular infection in the various organs of the rabbit reveals a pathognomonic response in the lungs within 24 hours; the specific response in the liver, spleen, lymph glands, and bone marrow, follows from the 6th to the 14th days. 2. The development and extent of the pathologic process has been analyzed in terms of the activity of monocytes and clasmatocytes. 3. The criteria for differentiating these mononuclear phagocytic cells into two strains have been analyzed and the technics discussed. 4. The clasmatocyte phagocytizes tubercle bacilli freely and fragments them, as it does all cellular and other debris. 5. The monocyte stimulated to metamorphose into the typical epithelioid and giant cell of the Langhans type retains the tubercle bacilli intact, with power to survive and multiply, over long periods of time. 6. The normal number of monocytes or the degree to which monoblasts may be stimulated to development and maturation, together with the activity of the clasmatocytes in destroying bacilli, in any particular region, would appear to be a function of the rapidity and extent of the local tubercular involvement. The Rockefeller University Press 1927-09-30 /pmc/articles/PMC2131307/ /pubmed/19869362 Text en Copyright © Copyright, 1927, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Sabin, Florence R.
Doan, Charles A.
THE RELATION OF MONOCYTES AND CLASMATOCYTES TO EARLY INFECTION IN RABBITS WITH BOVINE TUBERCLE BACILLI
title THE RELATION OF MONOCYTES AND CLASMATOCYTES TO EARLY INFECTION IN RABBITS WITH BOVINE TUBERCLE BACILLI
title_full THE RELATION OF MONOCYTES AND CLASMATOCYTES TO EARLY INFECTION IN RABBITS WITH BOVINE TUBERCLE BACILLI
title_fullStr THE RELATION OF MONOCYTES AND CLASMATOCYTES TO EARLY INFECTION IN RABBITS WITH BOVINE TUBERCLE BACILLI
title_full_unstemmed THE RELATION OF MONOCYTES AND CLASMATOCYTES TO EARLY INFECTION IN RABBITS WITH BOVINE TUBERCLE BACILLI
title_short THE RELATION OF MONOCYTES AND CLASMATOCYTES TO EARLY INFECTION IN RABBITS WITH BOVINE TUBERCLE BACILLI
title_sort relation of monocytes and clasmatocytes to early infection in rabbits with bovine tubercle bacilli
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2131307/
https://www.ncbi.nlm.nih.gov/pubmed/19869362
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