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THE RÔLE OF THE RETICULO-ENDOTHELIAL SYSTEM IN IMMUNITY : V. PHENOMENA OF PASSIVE IMMUNITY IN BLOCKED AND SPLENECTOMIZED MICE.

1. Blockade of the reticulo-endothelial system by means of one intravenous injection of India ink as well as splenectomy did not alter the course of either Pneumococcus Type I infection or tetanus intoxication in mice. 2. The protective action of Antipneumococcus Type I serum against the correspondi...

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Detalles Bibliográficos
Autor principal: Jungeblut, C. W.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1928
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2131355/
https://www.ncbi.nlm.nih.gov/pubmed/19869412
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author Jungeblut, C. W.
author_facet Jungeblut, C. W.
author_sort Jungeblut, C. W.
collection PubMed
description 1. Blockade of the reticulo-endothelial system by means of one intravenous injection of India ink as well as splenectomy did not alter the course of either Pneumococcus Type I infection or tetanus intoxication in mice. 2. The protective action of Antipneumococcus Type I serum against the corresponding infection, as determined by the injection of in vitro prepared mixtures of serum and culture, was definitely lower in mice which had received one blocking injection of India ink shortly before the test. 3. Titration of tetanus toxin and antitoxin in blocked and splenectomized mice gave results identical with those obtained in normal mice, if in vitro prepared and incubated toxin-antitoxin mixtures were injected. The degree of protection, however, conferred by a preceding dose of antitoxin against subsequent intoxication, was markedly lower in blocked mice than in normal control animals, this difference becoming more pronounced with the increase of the time interval.
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spelling pubmed-21313552008-04-18 THE RÔLE OF THE RETICULO-ENDOTHELIAL SYSTEM IN IMMUNITY : V. PHENOMENA OF PASSIVE IMMUNITY IN BLOCKED AND SPLENECTOMIZED MICE. Jungeblut, C. W. J Exp Med Article 1. Blockade of the reticulo-endothelial system by means of one intravenous injection of India ink as well as splenectomy did not alter the course of either Pneumococcus Type I infection or tetanus intoxication in mice. 2. The protective action of Antipneumococcus Type I serum against the corresponding infection, as determined by the injection of in vitro prepared mixtures of serum and culture, was definitely lower in mice which had received one blocking injection of India ink shortly before the test. 3. Titration of tetanus toxin and antitoxin in blocked and splenectomized mice gave results identical with those obtained in normal mice, if in vitro prepared and incubated toxin-antitoxin mixtures were injected. The degree of protection, however, conferred by a preceding dose of antitoxin against subsequent intoxication, was markedly lower in blocked mice than in normal control animals, this difference becoming more pronounced with the increase of the time interval. The Rockefeller University Press 1928-01-31 /pmc/articles/PMC2131355/ /pubmed/19869412 Text en Copyright © Copyright, 1928, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Jungeblut, C. W.
THE RÔLE OF THE RETICULO-ENDOTHELIAL SYSTEM IN IMMUNITY : V. PHENOMENA OF PASSIVE IMMUNITY IN BLOCKED AND SPLENECTOMIZED MICE.
title THE RÔLE OF THE RETICULO-ENDOTHELIAL SYSTEM IN IMMUNITY : V. PHENOMENA OF PASSIVE IMMUNITY IN BLOCKED AND SPLENECTOMIZED MICE.
title_full THE RÔLE OF THE RETICULO-ENDOTHELIAL SYSTEM IN IMMUNITY : V. PHENOMENA OF PASSIVE IMMUNITY IN BLOCKED AND SPLENECTOMIZED MICE.
title_fullStr THE RÔLE OF THE RETICULO-ENDOTHELIAL SYSTEM IN IMMUNITY : V. PHENOMENA OF PASSIVE IMMUNITY IN BLOCKED AND SPLENECTOMIZED MICE.
title_full_unstemmed THE RÔLE OF THE RETICULO-ENDOTHELIAL SYSTEM IN IMMUNITY : V. PHENOMENA OF PASSIVE IMMUNITY IN BLOCKED AND SPLENECTOMIZED MICE.
title_short THE RÔLE OF THE RETICULO-ENDOTHELIAL SYSTEM IN IMMUNITY : V. PHENOMENA OF PASSIVE IMMUNITY IN BLOCKED AND SPLENECTOMIZED MICE.
title_sort rôle of the reticulo-endothelial system in immunity : v. phenomena of passive immunity in blocked and splenectomized mice.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2131355/
https://www.ncbi.nlm.nih.gov/pubmed/19869412
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