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IMMUNOLOGICAL STUDIES IN RELATION TO THE SUPRARENAL GLAND : I. HEMOLYSIN FORMATION IN NORMAL RATS.

Hemolysin formation was studied in normal rats. It was found that a single intraperitoneal injection of 1 cc. of a 10 per cent suspension of red blood cells results in an optimum high hemolysin titer 5 days after injection. The titer gradually falls, the hemolysin disappearing from 14 to 18 days aft...

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Detalles Bibliográficos
Autores principales: Marmorston-Gottesman, J., Perla, David
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1928
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2131408/
https://www.ncbi.nlm.nih.gov/pubmed/19869439
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author Marmorston-Gottesman, J.
Perla, David
author_facet Marmorston-Gottesman, J.
Perla, David
author_sort Marmorston-Gottesman, J.
collection PubMed
description Hemolysin formation was studied in normal rats. It was found that a single intraperitoneal injection of 1 cc. of a 10 per cent suspension of red blood cells results in an optimum high hemolysin titer 5 days after injection. The titer gradually falls, the hemolysin disappearing from 14 to 18 days after the injection. Larger amounts are less effective in the production of amboceptor. Much smaller amounts produce correspondingly lower hemolysin titers, although the ratio is not mathematically proportional. Repeated injections of 1 cc. of a 10 per cent suspension of red blood cells at daily intervals or at intervals of 3 or 5 days for three injections do not increase the hemolysin titer over that resulting from a single injection. Furthermore, the curve of antibody formation following a single small intraperitoneal injec tion of red blood cells is not altered by subsequent injections of similar amounts.
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spelling pubmed-21314082008-04-18 IMMUNOLOGICAL STUDIES IN RELATION TO THE SUPRARENAL GLAND : I. HEMOLYSIN FORMATION IN NORMAL RATS. Marmorston-Gottesman, J. Perla, David J Exp Med Article Hemolysin formation was studied in normal rats. It was found that a single intraperitoneal injection of 1 cc. of a 10 per cent suspension of red blood cells results in an optimum high hemolysin titer 5 days after injection. The titer gradually falls, the hemolysin disappearing from 14 to 18 days after the injection. Larger amounts are less effective in the production of amboceptor. Much smaller amounts produce correspondingly lower hemolysin titers, although the ratio is not mathematically proportional. Repeated injections of 1 cc. of a 10 per cent suspension of red blood cells at daily intervals or at intervals of 3 or 5 days for three injections do not increase the hemolysin titer over that resulting from a single injection. Furthermore, the curve of antibody formation following a single small intraperitoneal injec tion of red blood cells is not altered by subsequent injections of similar amounts. The Rockefeller University Press 1928-04-30 /pmc/articles/PMC2131408/ /pubmed/19869439 Text en Copyright © Copyright, 1928, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Marmorston-Gottesman, J.
Perla, David
IMMUNOLOGICAL STUDIES IN RELATION TO THE SUPRARENAL GLAND : I. HEMOLYSIN FORMATION IN NORMAL RATS.
title IMMUNOLOGICAL STUDIES IN RELATION TO THE SUPRARENAL GLAND : I. HEMOLYSIN FORMATION IN NORMAL RATS.
title_full IMMUNOLOGICAL STUDIES IN RELATION TO THE SUPRARENAL GLAND : I. HEMOLYSIN FORMATION IN NORMAL RATS.
title_fullStr IMMUNOLOGICAL STUDIES IN RELATION TO THE SUPRARENAL GLAND : I. HEMOLYSIN FORMATION IN NORMAL RATS.
title_full_unstemmed IMMUNOLOGICAL STUDIES IN RELATION TO THE SUPRARENAL GLAND : I. HEMOLYSIN FORMATION IN NORMAL RATS.
title_short IMMUNOLOGICAL STUDIES IN RELATION TO THE SUPRARENAL GLAND : I. HEMOLYSIN FORMATION IN NORMAL RATS.
title_sort immunological studies in relation to the suprarenal gland : i. hemolysin formation in normal rats.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2131408/
https://www.ncbi.nlm.nih.gov/pubmed/19869439
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