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VARIANTS OF HEMOLYTIC STREPTOCOCCI; THEIR RELATION TO TYPE-SPECIFIC SUBSTANCE, VIRULENCE, AND TOXIN

Hemolytic streptococci, when freshly isolated from pathogenic lesions, form characteristic matt colonies and contain the type-specific substance M. Two varieties of matt cultures, equally rich in type-specific substance, can be distinguished by the virulence of the organisms for mice: (1) the matt v...

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Detalles Bibliográficos
Autores principales: Todd, E. W., Lancefield, R. C.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1928
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2131511/
https://www.ncbi.nlm.nih.gov/pubmed/19869519
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author Todd, E. W.
Lancefield, R. C.
author_facet Todd, E. W.
Lancefield, R. C.
author_sort Todd, E. W.
collection PubMed
description Hemolytic streptococci, when freshly isolated from pathogenic lesions, form characteristic matt colonies and contain the type-specific substance M. Two varieties of matt cultures, equally rich in type-specific substance, can be distinguished by the virulence of the organisms for mice: (1) the matt virulent variety, (2) the matt attenuated variety. The matt forms of hemolytic streptococci can be degraded to a third variety which forms glossy colonies and is always relatively avirulent. This is accomplished by prolonged cultivation on artificial media, by selection of colonies or by cultivation in homologous anti-M serum. In the process of degradation the cocci lose the major part of their type-specific substance but complete disappearance of type-specific substance rarely occurs. The glossy variant form, when fully degraded, is highly stable; but glossy cultures which have retained some type-specific substance can occasionally be reverted to the original matt form. Toxic filtrates from matt and glossy cultures are approximately equal in skin reactivity. No relationship appears to exist between virulence and toxigenicity.
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spelling pubmed-21315112008-04-18 VARIANTS OF HEMOLYTIC STREPTOCOCCI; THEIR RELATION TO TYPE-SPECIFIC SUBSTANCE, VIRULENCE, AND TOXIN Todd, E. W. Lancefield, R. C. J Exp Med Article Hemolytic streptococci, when freshly isolated from pathogenic lesions, form characteristic matt colonies and contain the type-specific substance M. Two varieties of matt cultures, equally rich in type-specific substance, can be distinguished by the virulence of the organisms for mice: (1) the matt virulent variety, (2) the matt attenuated variety. The matt forms of hemolytic streptococci can be degraded to a third variety which forms glossy colonies and is always relatively avirulent. This is accomplished by prolonged cultivation on artificial media, by selection of colonies or by cultivation in homologous anti-M serum. In the process of degradation the cocci lose the major part of their type-specific substance but complete disappearance of type-specific substance rarely occurs. The glossy variant form, when fully degraded, is highly stable; but glossy cultures which have retained some type-specific substance can occasionally be reverted to the original matt form. Toxic filtrates from matt and glossy cultures are approximately equal in skin reactivity. No relationship appears to exist between virulence and toxigenicity. The Rockefeller University Press 1928-11-30 /pmc/articles/PMC2131511/ /pubmed/19869519 Text en Copyright © Copyright, 1928, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Todd, E. W.
Lancefield, R. C.
VARIANTS OF HEMOLYTIC STREPTOCOCCI; THEIR RELATION TO TYPE-SPECIFIC SUBSTANCE, VIRULENCE, AND TOXIN
title VARIANTS OF HEMOLYTIC STREPTOCOCCI; THEIR RELATION TO TYPE-SPECIFIC SUBSTANCE, VIRULENCE, AND TOXIN
title_full VARIANTS OF HEMOLYTIC STREPTOCOCCI; THEIR RELATION TO TYPE-SPECIFIC SUBSTANCE, VIRULENCE, AND TOXIN
title_fullStr VARIANTS OF HEMOLYTIC STREPTOCOCCI; THEIR RELATION TO TYPE-SPECIFIC SUBSTANCE, VIRULENCE, AND TOXIN
title_full_unstemmed VARIANTS OF HEMOLYTIC STREPTOCOCCI; THEIR RELATION TO TYPE-SPECIFIC SUBSTANCE, VIRULENCE, AND TOXIN
title_short VARIANTS OF HEMOLYTIC STREPTOCOCCI; THEIR RELATION TO TYPE-SPECIFIC SUBSTANCE, VIRULENCE, AND TOXIN
title_sort variants of hemolytic streptococci; their relation to type-specific substance, virulence, and toxin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2131511/
https://www.ncbi.nlm.nih.gov/pubmed/19869519
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