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THE REVERSION OF R TO S PNEUMOCOCCI
A study was made of the behavior of R pneumococcus strains under various experimental conditions. It was found that daughter colonies frequently appeared among the R forms and in some instances tended to replace the typical R forms. The daughter strain produced colonies with shiny surfaces which wer...
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1929
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2131530/ https://www.ncbi.nlm.nih.gov/pubmed/19869545 |
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author | Reimann, Hobart A. |
author_facet | Reimann, Hobart A. |
author_sort | Reimann, Hobart A. |
collection | PubMed |
description | A study was made of the behavior of R pneumococcus strains under various experimental conditions. It was found that daughter colonies frequently appeared among the R forms and in some instances tended to replace the typical R forms. The daughter strain produced colonies with shiny surfaces which were morphologically indistinguishable from genuine S colonies although the characteristics of the bacteria comprising them conformed to the R variety. Both R and daughter forms which had resided for long periods of time in vivo have been converted into virulent forms. Strains of R pneumococci which seemed irreversible were apparently converted into S forms by applying the methods of Griffith. A general consideration of the information derived during the recent experimental studies indicates that virulent S pneumococci may dissociate into the R form in vivo, that the R forms may be occasionally found in the sputum of pneumonia patients and also may reside or lie dormant in vivo for a considerable period of time. It has been shown that under favorable circumstances bacteria of the R form may spontaneously revert to the original S form or by special methods may even transform into S forms of another type. |
format | Text |
id | pubmed-2131530 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1929 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21315302008-04-18 THE REVERSION OF R TO S PNEUMOCOCCI Reimann, Hobart A. J Exp Med Article A study was made of the behavior of R pneumococcus strains under various experimental conditions. It was found that daughter colonies frequently appeared among the R forms and in some instances tended to replace the typical R forms. The daughter strain produced colonies with shiny surfaces which were morphologically indistinguishable from genuine S colonies although the characteristics of the bacteria comprising them conformed to the R variety. Both R and daughter forms which had resided for long periods of time in vivo have been converted into virulent forms. Strains of R pneumococci which seemed irreversible were apparently converted into S forms by applying the methods of Griffith. A general consideration of the information derived during the recent experimental studies indicates that virulent S pneumococci may dissociate into the R form in vivo, that the R forms may be occasionally found in the sputum of pneumonia patients and also may reside or lie dormant in vivo for a considerable period of time. It has been shown that under favorable circumstances bacteria of the R form may spontaneously revert to the original S form or by special methods may even transform into S forms of another type. The Rockefeller University Press 1929-01-31 /pmc/articles/PMC2131530/ /pubmed/19869545 Text en Copyright © Copyright, 1929, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Reimann, Hobart A. THE REVERSION OF R TO S PNEUMOCOCCI |
title | THE REVERSION OF R TO S PNEUMOCOCCI |
title_full | THE REVERSION OF R TO S PNEUMOCOCCI |
title_fullStr | THE REVERSION OF R TO S PNEUMOCOCCI |
title_full_unstemmed | THE REVERSION OF R TO S PNEUMOCOCCI |
title_short | THE REVERSION OF R TO S PNEUMOCOCCI |
title_sort | reversion of r to s pneumococci |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2131530/ https://www.ncbi.nlm.nih.gov/pubmed/19869545 |
work_keys_str_mv | AT reimannhobarta thereversionofrtospneumococci AT reimannhobarta reversionofrtospneumococci |