THE RELATION OF CHROMATIN TO HEMOGLOBIN AND BILIRUBIN

1. Attention is directed to the diversity of opinion among investigators regarding the site and manner of hemoglobin formation in the body and its relation to bile pigment metabolism. 2. It is probable that in forming new hypotheses on this subject the earlier work of A. B. Macallum on the relation...

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Autor principal: Riecker, Herman H.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1929
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2131597/
https://www.ncbi.nlm.nih.gov/pubmed/19869592
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author Riecker, Herman H.
author_facet Riecker, Herman H.
author_sort Riecker, Herman H.
collection PubMed
description 1. Attention is directed to the diversity of opinion among investigators regarding the site and manner of hemoglobin formation in the body and its relation to bile pigment metabolism. 2. It is probable that in forming new hypotheses on this subject the earlier work of A. B. Macallum on the relation of chromatin to hemoglobin formation has not received sufficient consideration. 3. It has been shown by means of microchemical iron stains of the bone marrow cells, that the iron content of the hematoblast is increased during rapid hemoglobin production in simple anemia. 4. This fact is compatible with the work of Macallum who believed that hemoglobin is derived from the chromatin of the hematoblast. It does not support a theory that hemoglobin is formed as a part of a circulating pigment. 5. It is suggested that bilirubin is derived from the chromatin of body cells through the intermediary stages of the respiratory pigments, hemoglobin and cytochrome, from erythrocytes and other cells, respectively.
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spelling pubmed-21315972008-04-18 THE RELATION OF CHROMATIN TO HEMOGLOBIN AND BILIRUBIN Riecker, Herman H. J Exp Med Article 1. Attention is directed to the diversity of opinion among investigators regarding the site and manner of hemoglobin formation in the body and its relation to bile pigment metabolism. 2. It is probable that in forming new hypotheses on this subject the earlier work of A. B. Macallum on the relation of chromatin to hemoglobin formation has not received sufficient consideration. 3. It has been shown by means of microchemical iron stains of the bone marrow cells, that the iron content of the hematoblast is increased during rapid hemoglobin production in simple anemia. 4. This fact is compatible with the work of Macallum who believed that hemoglobin is derived from the chromatin of the hematoblast. It does not support a theory that hemoglobin is formed as a part of a circulating pigment. 5. It is suggested that bilirubin is derived from the chromatin of body cells through the intermediary stages of the respiratory pigments, hemoglobin and cytochrome, from erythrocytes and other cells, respectively. The Rockefeller University Press 1929-05-31 /pmc/articles/PMC2131597/ /pubmed/19869592 Text en Copyright © Copyright, 1929, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Riecker, Herman H.
THE RELATION OF CHROMATIN TO HEMOGLOBIN AND BILIRUBIN
title THE RELATION OF CHROMATIN TO HEMOGLOBIN AND BILIRUBIN
title_full THE RELATION OF CHROMATIN TO HEMOGLOBIN AND BILIRUBIN
title_fullStr THE RELATION OF CHROMATIN TO HEMOGLOBIN AND BILIRUBIN
title_full_unstemmed THE RELATION OF CHROMATIN TO HEMOGLOBIN AND BILIRUBIN
title_short THE RELATION OF CHROMATIN TO HEMOGLOBIN AND BILIRUBIN
title_sort relation of chromatin to hemoglobin and bilirubin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2131597/
https://www.ncbi.nlm.nih.gov/pubmed/19869592
work_keys_str_mv AT rieckerhermanh therelationofchromatintohemoglobinandbilirubin
AT rieckerhermanh relationofchromatintohemoglobinandbilirubin

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