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CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS : I. THE SYNTHESIS OFp-AMINOPHENOL β-GLUCOSIDE, p-AMINOPHENOL β-GALACTOSIDE, AND THEIR COUPLING WITH SERUM GLOBULIN
It has been demonstrated that many multiples of minimal doses of Bacillus typhosus reacting factors can be neutralized by specific immune sera. The potency of a given serum can be conveniently titrated against increasing amounts of reacting factors. If the immune serum is diluted or if the amount of...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1929
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2131644/ https://www.ncbi.nlm.nih.gov/pubmed/19869644 |
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author | Goebel, Walther F. Avery, Oswald T. |
author_facet | Goebel, Walther F. Avery, Oswald T. |
author_sort | Goebel, Walther F. |
collection | PubMed |
description | It has been demonstrated that many multiples of minimal doses of Bacillus typhosus reacting factors can be neutralized by specific immune sera. The potency of a given serum can be conveniently titrated against increasing amounts of reacting factors. If the immune serum is diluted or if the amount of the reacting factors is too large for a given amount of serum, there is obtained neutralization but only irregularly. Normal and heterologous sera (therapeutic meningococcus and erysipelas horse sera) free of normal agglutinins or possessing normal agglutinins of a low titer (1:16) for Bacillus typhosus are not able to neutralize the reacting factors. There is obtained questionable neutralization with a serum possessing normal Bacillus typhosus agglutinins in dilution 1:64. The titer of the neutralizing antibodies increases in the course of immunization. Immune sera exercise a definite protection against the mortality induced by intravenous injection of Bacillus typhosus culture filtrates. |
format | Text |
id | pubmed-2131644 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1929 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21316442008-04-18 CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS : I. THE SYNTHESIS OFp-AMINOPHENOL β-GLUCOSIDE, p-AMINOPHENOL β-GALACTOSIDE, AND THEIR COUPLING WITH SERUM GLOBULIN Goebel, Walther F. Avery, Oswald T. J Exp Med Article It has been demonstrated that many multiples of minimal doses of Bacillus typhosus reacting factors can be neutralized by specific immune sera. The potency of a given serum can be conveniently titrated against increasing amounts of reacting factors. If the immune serum is diluted or if the amount of the reacting factors is too large for a given amount of serum, there is obtained neutralization but only irregularly. Normal and heterologous sera (therapeutic meningococcus and erysipelas horse sera) free of normal agglutinins or possessing normal agglutinins of a low titer (1:16) for Bacillus typhosus are not able to neutralize the reacting factors. There is obtained questionable neutralization with a serum possessing normal Bacillus typhosus agglutinins in dilution 1:64. The titer of the neutralizing antibodies increases in the course of immunization. Immune sera exercise a definite protection against the mortality induced by intravenous injection of Bacillus typhosus culture filtrates. The Rockefeller University Press 1929-09-30 /pmc/articles/PMC2131644/ /pubmed/19869644 Text en Copyright © Copyright, 1929, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Goebel, Walther F. Avery, Oswald T. CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS : I. THE SYNTHESIS OFp-AMINOPHENOL β-GLUCOSIDE, p-AMINOPHENOL β-GALACTOSIDE, AND THEIR COUPLING WITH SERUM GLOBULIN |
title | CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS : I. THE SYNTHESIS OFp-AMINOPHENOL β-GLUCOSIDE, p-AMINOPHENOL β-GALACTOSIDE, AND THEIR COUPLING WITH SERUM GLOBULIN |
title_full | CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS : I. THE SYNTHESIS OFp-AMINOPHENOL β-GLUCOSIDE, p-AMINOPHENOL β-GALACTOSIDE, AND THEIR COUPLING WITH SERUM GLOBULIN |
title_fullStr | CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS : I. THE SYNTHESIS OFp-AMINOPHENOL β-GLUCOSIDE, p-AMINOPHENOL β-GALACTOSIDE, AND THEIR COUPLING WITH SERUM GLOBULIN |
title_full_unstemmed | CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS : I. THE SYNTHESIS OFp-AMINOPHENOL β-GLUCOSIDE, p-AMINOPHENOL β-GALACTOSIDE, AND THEIR COUPLING WITH SERUM GLOBULIN |
title_short | CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS : I. THE SYNTHESIS OFp-AMINOPHENOL β-GLUCOSIDE, p-AMINOPHENOL β-GALACTOSIDE, AND THEIR COUPLING WITH SERUM GLOBULIN |
title_sort | chemo-immunological studies on conjugated carbohydrate-proteins : i. the synthesis ofp-aminophenol β-glucoside, p-aminophenol β-galactoside, and their coupling with serum globulin |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2131644/ https://www.ncbi.nlm.nih.gov/pubmed/19869644 |
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