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Grb7 SH2 domain structure and interactions with a cyclic peptide inhibitor of cancer cell migration and proliferation

BACKGROUND: Human growth factor receptor bound protein 7 (Grb7) is an adapter protein that mediates the coupling of tyrosine kinases with their downstream signaling pathways. Grb7 is frequently overexpressed in invasive and metastatic human cancers and is implicated in cancer progression via its int...

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Detalles Bibliográficos
Autores principales:	Porter, Corrine J, Matthews, Jacqueline M, Mackay, Joel P, Pursglove, Sharon E, Schmidberger, Jason W, Leedman, Peter J, Pero, Stephanie C, Krag, David N, Wilce, Matthew CJ, Wilce, Jacqueline A
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2007
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2131756/ https://www.ncbi.nlm.nih.gov/pubmed/17894853 http://dx.doi.org/10.1186/1472-6807-7-58

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