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A Tale of Switched Functions: From Cyclooxygenase Inhibition to M-Channel Modulation in New Diphenylamine Derivatives
Cyclooxygenase (COX) enzymes are molecular targets of nonsteroidal anti-inflammatory drugs (NSAIDs), the most used medication worldwide. However, the COX enzymes are not the sole molecular targets of NSAIDs. Recently, we showed that two NSAIDs, diclofenac and meclofenamate, also act as openers of Kv...
Autores principales: | Peretz, Asher, Degani-Katzav, Nurit, Talmon, Maya, Danieli, Eyal, Gopin, Anna, Malka, Eti, Nachman, Rachel, Raz, Amiram, Shabat, Doron, Attali, Bernard |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2131780/ https://www.ncbi.nlm.nih.gov/pubmed/18159230 http://dx.doi.org/10.1371/journal.pone.0001332 |
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