High Levels of MeCP2 Depress MHC Class I Expression in Neuronal Cells

BACKGROUND: The expression of MHC class I genes is repressed in mature neurons. The molecular basis of this regulation is poorly understood, but the genes are particularly rich in CpG islands. MeCP2 is a transcriptional repressor that binds to methylated CpG dinucleotides; mutations in this protein...

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Detalles Bibliográficos
Autores principales: Miralvès, Julie, Magdeleine, Eddy, Kaddoum, Lara, Brun, Hélène, Peries, Sophie, Joly, Etienne
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2131781/
https://www.ncbi.nlm.nih.gov/pubmed/18159237
http://dx.doi.org/10.1371/journal.pone.0001354

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2131781/
https://www.ncbi.nlm.nih.gov/pubmed/18159237
http://dx.doi.org/10.1371/journal.pone.0001354

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