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High Levels of MeCP2 Depress MHC Class I Expression in Neuronal Cells
BACKGROUND: The expression of MHC class I genes is repressed in mature neurons. The molecular basis of this regulation is poorly understood, but the genes are particularly rich in CpG islands. MeCP2 is a transcriptional repressor that binds to methylated CpG dinucleotides; mutations in this protein...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2131781/ https://www.ncbi.nlm.nih.gov/pubmed/18159237 http://dx.doi.org/10.1371/journal.pone.0001354 |