A POTENT ANTIPOLIOMYELITIC HORSE SERUM CONCENTRATE AND ITS EXPERIMENTAL USE IN INFECTED MONKEYS

1. The horse, apparently itself unsusceptible to poliomyelitis, can be stimulated in certain cases but not all to the production of virucidal antibodies. 2. The virucidal potency of such immune serum can be raised to a point comparable to that of human convalescent serum and when concentrated and re...

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Detalles Bibliográficos
Autores principales: Weyer, Elliott R., Park, William H., Banzhaf, E. J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1931
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2131982/
https://www.ncbi.nlm.nih.gov/pubmed/19869864
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author Weyer, Elliott R.
Park, William H.
Banzhaf, E. J.
author_facet Weyer, Elliott R.
Park, William H.
Banzhaf, E. J.
author_sort Weyer, Elliott R.
collection PubMed
description 1. The horse, apparently itself unsusceptible to poliomyelitis, can be stimulated in certain cases but not all to the production of virucidal antibodies. 2. The virucidal potency of such immune serum can be raised to a point comparable to that of human convalescent serum and when concentrated and refined exhibits a four-fold increase in potency. 3. Such concentrates have proved effective in the prevention of paralysis in inoculated monkeys when given intraspinously before the onset of paralysis. 4. Treatment has been found more effective when therapeutic serums are given through the spinal route. 5. Pooled serum from "normal" adult donors has proved effective in neutralizing virus but its potency is approximately one-half that of convalescent serum.
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spelling pubmed-21319822008-04-18 A POTENT ANTIPOLIOMYELITIC HORSE SERUM CONCENTRATE AND ITS EXPERIMENTAL USE IN INFECTED MONKEYS Weyer, Elliott R. Park, William H. Banzhaf, E. J. J Exp Med Article 1. The horse, apparently itself unsusceptible to poliomyelitis, can be stimulated in certain cases but not all to the production of virucidal antibodies. 2. The virucidal potency of such immune serum can be raised to a point comparable to that of human convalescent serum and when concentrated and refined exhibits a four-fold increase in potency. 3. Such concentrates have proved effective in the prevention of paralysis in inoculated monkeys when given intraspinously before the onset of paralysis. 4. Treatment has been found more effective when therapeutic serums are given through the spinal route. 5. Pooled serum from "normal" adult donors has proved effective in neutralizing virus but its potency is approximately one-half that of convalescent serum. The Rockefeller University Press 1931-03-31 /pmc/articles/PMC2131982/ /pubmed/19869864 Text en Copyright © Copyright, 1931, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Weyer, Elliott R.
Park, William H.
Banzhaf, E. J.
A POTENT ANTIPOLIOMYELITIC HORSE SERUM CONCENTRATE AND ITS EXPERIMENTAL USE IN INFECTED MONKEYS
title A POTENT ANTIPOLIOMYELITIC HORSE SERUM CONCENTRATE AND ITS EXPERIMENTAL USE IN INFECTED MONKEYS
title_full A POTENT ANTIPOLIOMYELITIC HORSE SERUM CONCENTRATE AND ITS EXPERIMENTAL USE IN INFECTED MONKEYS
title_fullStr A POTENT ANTIPOLIOMYELITIC HORSE SERUM CONCENTRATE AND ITS EXPERIMENTAL USE IN INFECTED MONKEYS
title_full_unstemmed A POTENT ANTIPOLIOMYELITIC HORSE SERUM CONCENTRATE AND ITS EXPERIMENTAL USE IN INFECTED MONKEYS
title_short A POTENT ANTIPOLIOMYELITIC HORSE SERUM CONCENTRATE AND ITS EXPERIMENTAL USE IN INFECTED MONKEYS
title_sort potent antipoliomyelitic horse serum concentrate and its experimental use in infected monkeys
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2131982/
https://www.ncbi.nlm.nih.gov/pubmed/19869864
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