Cargando…

ACTIVE IMMUNIZATION AGAINST POLIOMYELITIS IN MONKEYS

1. A combination of poliomyelitis virus and specific human serum is effective for the production of active immunity. 2. For each gram of active virus given intradermally as an emulsion, 6 cc. of human immune serum, injected subcutaneously, was required in our experiments to protect a monkey from par...

Descripción completa

Detalles Bibliográficos
Autores principales: Brodie, Maurice, Goldbloom, Alton
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1931
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132035/
https://www.ncbi.nlm.nih.gov/pubmed/19869891
_version_ 1782142352968646656
author Brodie, Maurice
Goldbloom, Alton
author_facet Brodie, Maurice
Goldbloom, Alton
author_sort Brodie, Maurice
collection PubMed
description 1. A combination of poliomyelitis virus and specific human serum is effective for the production of active immunity. 2. For each gram of active virus given intradermally as an emulsion, 6 cc. of human immune serum, injected subcutaneously, was required in our experiments to protect a monkey from paralysis. Some degree of active immunity was induced. 3. Immunity, without symptom of the disease, was secured when the serum was given at the time of inoculation, or within 3 days preceding or following inoculation of the virus. 4. For the production of immunity, virus, preceded by serum administration, is probably less effective than when it is given simultaneously with, or before, the injection of serum. 5. The virus neutralization test is more sensitive than the direct intracerebral test for determining the production of immunity.
format Text
id pubmed-2132035
institution National Center for Biotechnology Information
language English
publishDate 1931
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21320352008-04-18 ACTIVE IMMUNIZATION AGAINST POLIOMYELITIS IN MONKEYS Brodie, Maurice Goldbloom, Alton J Exp Med Article 1. A combination of poliomyelitis virus and specific human serum is effective for the production of active immunity. 2. For each gram of active virus given intradermally as an emulsion, 6 cc. of human immune serum, injected subcutaneously, was required in our experiments to protect a monkey from paralysis. Some degree of active immunity was induced. 3. Immunity, without symptom of the disease, was secured when the serum was given at the time of inoculation, or within 3 days preceding or following inoculation of the virus. 4. For the production of immunity, virus, preceded by serum administration, is probably less effective than when it is given simultaneously with, or before, the injection of serum. 5. The virus neutralization test is more sensitive than the direct intracerebral test for determining the production of immunity. The Rockefeller University Press 1931-05-31 /pmc/articles/PMC2132035/ /pubmed/19869891 Text en Copyright © Copyright, 1931, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Brodie, Maurice
Goldbloom, Alton
ACTIVE IMMUNIZATION AGAINST POLIOMYELITIS IN MONKEYS
title ACTIVE IMMUNIZATION AGAINST POLIOMYELITIS IN MONKEYS
title_full ACTIVE IMMUNIZATION AGAINST POLIOMYELITIS IN MONKEYS
title_fullStr ACTIVE IMMUNIZATION AGAINST POLIOMYELITIS IN MONKEYS
title_full_unstemmed ACTIVE IMMUNIZATION AGAINST POLIOMYELITIS IN MONKEYS
title_short ACTIVE IMMUNIZATION AGAINST POLIOMYELITIS IN MONKEYS
title_sort active immunization against poliomyelitis in monkeys
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132035/
https://www.ncbi.nlm.nih.gov/pubmed/19869891
work_keys_str_mv AT brodiemaurice activeimmunizationagainstpoliomyelitisinmonkeys
AT goldbloomalton activeimmunizationagainstpoliomyelitisinmonkeys