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ACTIVE IMMUNIZATION AGAINST POLIOMYELITIS IN MONKEYS
1. A combination of poliomyelitis virus and specific human serum is effective for the production of active immunity. 2. For each gram of active virus given intradermally as an emulsion, 6 cc. of human immune serum, injected subcutaneously, was required in our experiments to protect a monkey from par...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
1931
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132035/ https://www.ncbi.nlm.nih.gov/pubmed/19869891 |
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author | Brodie, Maurice Goldbloom, Alton |
author_facet | Brodie, Maurice Goldbloom, Alton |
author_sort | Brodie, Maurice |
collection | PubMed |
description | 1. A combination of poliomyelitis virus and specific human serum is effective for the production of active immunity. 2. For each gram of active virus given intradermally as an emulsion, 6 cc. of human immune serum, injected subcutaneously, was required in our experiments to protect a monkey from paralysis. Some degree of active immunity was induced. 3. Immunity, without symptom of the disease, was secured when the serum was given at the time of inoculation, or within 3 days preceding or following inoculation of the virus. 4. For the production of immunity, virus, preceded by serum administration, is probably less effective than when it is given simultaneously with, or before, the injection of serum. 5. The virus neutralization test is more sensitive than the direct intracerebral test for determining the production of immunity. |
format | Text |
id | pubmed-2132035 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1931 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21320352008-04-18 ACTIVE IMMUNIZATION AGAINST POLIOMYELITIS IN MONKEYS Brodie, Maurice Goldbloom, Alton J Exp Med Article 1. A combination of poliomyelitis virus and specific human serum is effective for the production of active immunity. 2. For each gram of active virus given intradermally as an emulsion, 6 cc. of human immune serum, injected subcutaneously, was required in our experiments to protect a monkey from paralysis. Some degree of active immunity was induced. 3. Immunity, without symptom of the disease, was secured when the serum was given at the time of inoculation, or within 3 days preceding or following inoculation of the virus. 4. For the production of immunity, virus, preceded by serum administration, is probably less effective than when it is given simultaneously with, or before, the injection of serum. 5. The virus neutralization test is more sensitive than the direct intracerebral test for determining the production of immunity. The Rockefeller University Press 1931-05-31 /pmc/articles/PMC2132035/ /pubmed/19869891 Text en Copyright © Copyright, 1931, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Brodie, Maurice Goldbloom, Alton ACTIVE IMMUNIZATION AGAINST POLIOMYELITIS IN MONKEYS |
title | ACTIVE IMMUNIZATION AGAINST POLIOMYELITIS IN MONKEYS |
title_full | ACTIVE IMMUNIZATION AGAINST POLIOMYELITIS IN MONKEYS |
title_fullStr | ACTIVE IMMUNIZATION AGAINST POLIOMYELITIS IN MONKEYS |
title_full_unstemmed | ACTIVE IMMUNIZATION AGAINST POLIOMYELITIS IN MONKEYS |
title_short | ACTIVE IMMUNIZATION AGAINST POLIOMYELITIS IN MONKEYS |
title_sort | active immunization against poliomyelitis in monkeys |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132035/ https://www.ncbi.nlm.nih.gov/pubmed/19869891 |
work_keys_str_mv | AT brodiemaurice activeimmunizationagainstpoliomyelitisinmonkeys AT goldbloomalton activeimmunizationagainstpoliomyelitisinmonkeys |