STUDIES ON BARTONELLA MURIS ANEMIA : V. COMPENSATORY PHENOMENA FOLLOWING SPLENECTOMY IN THE ADULT ALBINO RAT

In Bartonella muris carrier stock certain changes are observed in the lymphoblastic and reticular and endothelial elements after splenectomy and recovery from the anemia. These changes appear 3 to 5 months after splenectomy and are associated with immunity to further infection with Bartonella muris. The changes consist primarily of hyperplasia of hemolymph tissue, hyperplasia of reticular and endothelial elements of lymph nodes, the formation of lymphoblastic foci periportally in the liver and peribronchially and perivascularly in the lung, regeneration of all elements of the thymus and marked hyperplasia of all elements of the bone marrow (increased hematopoiesis).