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ARTIFICIAL ACIDOSIS IN TRYPANOSOMA LEWISI INFECTIONS, AND ITS BEARING ON THE PATHOGENIC ACTION OF TRYPANOSOMA EQUIPERDUM

When the alkali reserve is artificially lowered in rats infected with Trypanosoma lewisi, the number of parasites in the blood is increased. The increase is large in the early stages of the disease, and becomes less marked as the number crisis is approached. Near the crisis, and after it, a lowered...

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Detalles Bibliográficos
Autores principales: Linton, Richard W., Poindexter, H. A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1931
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132056/
https://www.ncbi.nlm.nih.gov/pubmed/19869949
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author Linton, Richard W.
Poindexter, H. A.
author_facet Linton, Richard W.
Poindexter, H. A.
author_sort Linton, Richard W.
collection PubMed
description When the alkali reserve is artificially lowered in rats infected with Trypanosoma lewisi, the number of parasites in the blood is increased. The increase is large in the early stages of the disease, and becomes less marked as the number crisis is approached. Near the crisis, and after it, a lowered alkali reserve does not affect the number of trypanosomes. It has been shown that the observed increase does not result from a contraction of the capillaries of the inner organs, which would throw a large number of trypanosomes into the peripheral circulation; nor is the increase due to a greater reproductive activity on the part of the trypanosomes. The increase must, therefore, be due to an inhibition of the destructive forces of the host. It is suggested that the known production of organic acids by the pathogenic trypanosomes plays a similar rôle in inhibiting the destructive mechanism of the host, and is therefore of significance in the pathogenic activity of these organisms.
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spelling pubmed-21320562008-04-18 ARTIFICIAL ACIDOSIS IN TRYPANOSOMA LEWISI INFECTIONS, AND ITS BEARING ON THE PATHOGENIC ACTION OF TRYPANOSOMA EQUIPERDUM Linton, Richard W. Poindexter, H. A. J Exp Med Article When the alkali reserve is artificially lowered in rats infected with Trypanosoma lewisi, the number of parasites in the blood is increased. The increase is large in the early stages of the disease, and becomes less marked as the number crisis is approached. Near the crisis, and after it, a lowered alkali reserve does not affect the number of trypanosomes. It has been shown that the observed increase does not result from a contraction of the capillaries of the inner organs, which would throw a large number of trypanosomes into the peripheral circulation; nor is the increase due to a greater reproductive activity on the part of the trypanosomes. The increase must, therefore, be due to an inhibition of the destructive forces of the host. It is suggested that the known production of organic acids by the pathogenic trypanosomes plays a similar rôle in inhibiting the destructive mechanism of the host, and is therefore of significance in the pathogenic activity of these organisms. The Rockefeller University Press 1931-10-31 /pmc/articles/PMC2132056/ /pubmed/19869949 Text en Copyright © Copyright, 1931, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Linton, Richard W.
Poindexter, H. A.
ARTIFICIAL ACIDOSIS IN TRYPANOSOMA LEWISI INFECTIONS, AND ITS BEARING ON THE PATHOGENIC ACTION OF TRYPANOSOMA EQUIPERDUM
title ARTIFICIAL ACIDOSIS IN TRYPANOSOMA LEWISI INFECTIONS, AND ITS BEARING ON THE PATHOGENIC ACTION OF TRYPANOSOMA EQUIPERDUM
title_full ARTIFICIAL ACIDOSIS IN TRYPANOSOMA LEWISI INFECTIONS, AND ITS BEARING ON THE PATHOGENIC ACTION OF TRYPANOSOMA EQUIPERDUM
title_fullStr ARTIFICIAL ACIDOSIS IN TRYPANOSOMA LEWISI INFECTIONS, AND ITS BEARING ON THE PATHOGENIC ACTION OF TRYPANOSOMA EQUIPERDUM
title_full_unstemmed ARTIFICIAL ACIDOSIS IN TRYPANOSOMA LEWISI INFECTIONS, AND ITS BEARING ON THE PATHOGENIC ACTION OF TRYPANOSOMA EQUIPERDUM
title_short ARTIFICIAL ACIDOSIS IN TRYPANOSOMA LEWISI INFECTIONS, AND ITS BEARING ON THE PATHOGENIC ACTION OF TRYPANOSOMA EQUIPERDUM
title_sort artificial acidosis in trypanosoma lewisi infections, and its bearing on the pathogenic action of trypanosoma equiperdum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132056/
https://www.ncbi.nlm.nih.gov/pubmed/19869949
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