THE EFFECT OF BILATERAL SUPRARENALECTOMY IN ADULT ALBINO RATS ON THE NATURAL AND ACQUIRED RESISTANCE TO BARTONELLA MURIS ANEMIA

Normal adult Wistar rats (non-carrier stock) are readily infected with Bartonella muris and develop a severe anemia if large amounts of infecting material are used. The normal adult rat of Wistar stock possesses a relatively high natural resistance to spontaneous infection with this organism. Bilate...

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Detalles Bibliográficos
Autores principales: Marmorston-Gottesman, J., Perla, David
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1932
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132077/
https://www.ncbi.nlm.nih.gov/pubmed/19869970
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author Marmorston-Gottesman, J.
Perla, David
author_facet Marmorston-Gottesman, J.
Perla, David
author_sort Marmorston-Gottesman, J.
collection PubMed
description Normal adult Wistar rats (non-carrier stock) are readily infected with Bartonella muris and develop a severe anemia if large amounts of infecting material are used. The normal adult rat of Wistar stock possesses a relatively high natural resistance to spontaneous infection with this organism. Bilateral suprarenalectomy in Wistar rats lowers the natural resistance to a subsequent infection with Bartonella muris. This procedure does not alter the type of tissue response to the virus but lowers the natural resistance of the rat to toxic effects of the infection. The acquired immunity to Bartonella muris conferred by a first infection is not broken down by subsequent suprarenalectomy. The mechanisms of acquired and natural resistance are dependent on different physiological processes in the organism and are not merely quantitative variations of the same process as is generally assumed.
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spelling pubmed-21320772008-04-18 THE EFFECT OF BILATERAL SUPRARENALECTOMY IN ADULT ALBINO RATS ON THE NATURAL AND ACQUIRED RESISTANCE TO BARTONELLA MURIS ANEMIA Marmorston-Gottesman, J. Perla, David J Exp Med Article Normal adult Wistar rats (non-carrier stock) are readily infected with Bartonella muris and develop a severe anemia if large amounts of infecting material are used. The normal adult rat of Wistar stock possesses a relatively high natural resistance to spontaneous infection with this organism. Bilateral suprarenalectomy in Wistar rats lowers the natural resistance to a subsequent infection with Bartonella muris. This procedure does not alter the type of tissue response to the virus but lowers the natural resistance of the rat to toxic effects of the infection. The acquired immunity to Bartonella muris conferred by a first infection is not broken down by subsequent suprarenalectomy. The mechanisms of acquired and natural resistance are dependent on different physiological processes in the organism and are not merely quantitative variations of the same process as is generally assumed. The Rockefeller University Press 1932-01-01 /pmc/articles/PMC2132077/ /pubmed/19869970 Text en Copyright © Copyright, 1932, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Marmorston-Gottesman, J.
Perla, David
THE EFFECT OF BILATERAL SUPRARENALECTOMY IN ADULT ALBINO RATS ON THE NATURAL AND ACQUIRED RESISTANCE TO BARTONELLA MURIS ANEMIA
title THE EFFECT OF BILATERAL SUPRARENALECTOMY IN ADULT ALBINO RATS ON THE NATURAL AND ACQUIRED RESISTANCE TO BARTONELLA MURIS ANEMIA
title_full THE EFFECT OF BILATERAL SUPRARENALECTOMY IN ADULT ALBINO RATS ON THE NATURAL AND ACQUIRED RESISTANCE TO BARTONELLA MURIS ANEMIA
title_fullStr THE EFFECT OF BILATERAL SUPRARENALECTOMY IN ADULT ALBINO RATS ON THE NATURAL AND ACQUIRED RESISTANCE TO BARTONELLA MURIS ANEMIA
title_full_unstemmed THE EFFECT OF BILATERAL SUPRARENALECTOMY IN ADULT ALBINO RATS ON THE NATURAL AND ACQUIRED RESISTANCE TO BARTONELLA MURIS ANEMIA
title_short THE EFFECT OF BILATERAL SUPRARENALECTOMY IN ADULT ALBINO RATS ON THE NATURAL AND ACQUIRED RESISTANCE TO BARTONELLA MURIS ANEMIA
title_sort effect of bilateral suprarenalectomy in adult albino rats on the natural and acquired resistance to bartonella muris anemia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132077/
https://www.ncbi.nlm.nih.gov/pubmed/19869970
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