ON THE SEROLOGICAL SPECIFICITY OF PEPTIDES

With the idea that studies on the serological properties of peptides may ultimately aid in the understanding of the precipitin reactions of proteins, antigens have been prepared containing aminobenzoylated dipeptides, namely glycyl-glycine, glycyl-d, l-leucine, d, l-leucyl-glycine and d, l-leucyl-d,...

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Detalles Bibliográficos
Autores principales: Landsteiner, K., van der Scheer, J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1932
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132133/
https://www.ncbi.nlm.nih.gov/pubmed/19870030
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author Landsteiner, K.
van der Scheer, J.
author_facet Landsteiner, K.
van der Scheer, J.
author_sort Landsteiner, K.
collection PubMed
description With the idea that studies on the serological properties of peptides may ultimately aid in the understanding of the precipitin reactions of proteins, antigens have been prepared containing aminobenzoylated dipeptides, namely glycyl-glycine, glycyl-d, l-leucine, d, l-leucyl-glycine and d, l-leucyl-d, l-leucine. These four antigens were found to be different serologically, their specificity depending on the structure of the terminal amino acid carrying the free carboxyl group, and to a less degree also on the second amino acid. The results were obtained by means of precipitin and inhibition tests. Analogies to observations on enzyme specificity are discussed.
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spelling pubmed-21321332008-04-18 ON THE SEROLOGICAL SPECIFICITY OF PEPTIDES Landsteiner, K. van der Scheer, J. J Exp Med Article With the idea that studies on the serological properties of peptides may ultimately aid in the understanding of the precipitin reactions of proteins, antigens have been prepared containing aminobenzoylated dipeptides, namely glycyl-glycine, glycyl-d, l-leucine, d, l-leucyl-glycine and d, l-leucyl-d, l-leucine. These four antigens were found to be different serologically, their specificity depending on the structure of the terminal amino acid carrying the free carboxyl group, and to a less degree also on the second amino acid. The results were obtained by means of precipitin and inhibition tests. Analogies to observations on enzyme specificity are discussed. The Rockefeller University Press 1932-04-30 /pmc/articles/PMC2132133/ /pubmed/19870030 Text en Copyright © Copyright, 1932, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Landsteiner, K.
van der Scheer, J.
ON THE SEROLOGICAL SPECIFICITY OF PEPTIDES
title ON THE SEROLOGICAL SPECIFICITY OF PEPTIDES
title_full ON THE SEROLOGICAL SPECIFICITY OF PEPTIDES
title_fullStr ON THE SEROLOGICAL SPECIFICITY OF PEPTIDES
title_full_unstemmed ON THE SEROLOGICAL SPECIFICITY OF PEPTIDES
title_short ON THE SEROLOGICAL SPECIFICITY OF PEPTIDES
title_sort on the serological specificity of peptides
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132133/
https://www.ncbi.nlm.nih.gov/pubmed/19870030
work_keys_str_mv AT landsteinerk ontheserologicalspecificityofpeptides
AT vanderscheerj ontheserologicalspecificityofpeptides

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