STUDIES ON THE SHWARTZMAN PHENOMENON : I. DETOXIFICATION OF MENINGOCOCCUS CULTURE FILTRATES

Formalin induces a considerable change in meningococcus culture filtrates. This consists of a marked decrease in toxidty as concerns both the Shwartzman phenomenon and the lethal effect, with relative preservation of the antibody-combining capacity and antigenicity. A similar modification occurs spo...

Descripción completa

Detalles Bibliográficos
Autor principal: Klein, Herbert M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1932
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132186/
https://www.ncbi.nlm.nih.gov/pubmed/19870087
_version_ 1782142388693630976
author Klein, Herbert M.
author_facet Klein, Herbert M.
author_sort Klein, Herbert M.
collection PubMed
description Formalin induces a considerable change in meningococcus culture filtrates. This consists of a marked decrease in toxidty as concerns both the Shwartzman phenomenon and the lethal effect, with relative preservation of the antibody-combining capacity and antigenicity. A similar modification occurs spontaneously in meningococcus culture filtrates on standing. Inasmuch as these changes parallel those occurring in the conversion of diphtheria toxin into toxoid, it is justifiable to consider such altered meningococcus toxin as meningococcus toxoid.
format Text
id pubmed-2132186
institution National Center for Biotechnology Information
language English
publishDate 1932
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21321862008-04-18 STUDIES ON THE SHWARTZMAN PHENOMENON : I. DETOXIFICATION OF MENINGOCOCCUS CULTURE FILTRATES Klein, Herbert M. J Exp Med Article Formalin induces a considerable change in meningococcus culture filtrates. This consists of a marked decrease in toxidty as concerns both the Shwartzman phenomenon and the lethal effect, with relative preservation of the antibody-combining capacity and antigenicity. A similar modification occurs spontaneously in meningococcus culture filtrates on standing. Inasmuch as these changes parallel those occurring in the conversion of diphtheria toxin into toxoid, it is justifiable to consider such altered meningococcus toxin as meningococcus toxoid. The Rockefeller University Press 1932-09-30 /pmc/articles/PMC2132186/ /pubmed/19870087 Text en Copyright © Copyright, 1932, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Klein, Herbert M.
STUDIES ON THE SHWARTZMAN PHENOMENON : I. DETOXIFICATION OF MENINGOCOCCUS CULTURE FILTRATES
title STUDIES ON THE SHWARTZMAN PHENOMENON : I. DETOXIFICATION OF MENINGOCOCCUS CULTURE FILTRATES
title_full STUDIES ON THE SHWARTZMAN PHENOMENON : I. DETOXIFICATION OF MENINGOCOCCUS CULTURE FILTRATES
title_fullStr STUDIES ON THE SHWARTZMAN PHENOMENON : I. DETOXIFICATION OF MENINGOCOCCUS CULTURE FILTRATES
title_full_unstemmed STUDIES ON THE SHWARTZMAN PHENOMENON : I. DETOXIFICATION OF MENINGOCOCCUS CULTURE FILTRATES
title_short STUDIES ON THE SHWARTZMAN PHENOMENON : I. DETOXIFICATION OF MENINGOCOCCUS CULTURE FILTRATES
title_sort studies on the shwartzman phenomenon : i. detoxification of meningococcus culture filtrates
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132186/
https://www.ncbi.nlm.nih.gov/pubmed/19870087
work_keys_str_mv AT kleinherbertm studiesontheshwartzmanphenomenonidetoxificationofmeningococcusculturefiltrates

Ejemplares similares