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STUDIES ON TYPHUS FEVER : X. FURTHER EXPERIMENTS ON ACTIVE IMMUNIZATION AGAINST TYPHUS FEVER WITH KILLED RICKETTSIA

1. Vaccines consisting of formalinized Rickettsiae of Mexican typhus fever, obtained by our X-ray rat method, produce definite resistance in guinea pigs to subsequent infection with the virus of this disease. 2. The resistance so produced amounts to complete immunity when the subsequent infectious d...

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Detalles Bibliográficos
Autores principales: Zinsser, Hans, Castaneda, M. Ruiz
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1933
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132240/
https://www.ncbi.nlm.nih.gov/pubmed/19870137
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author Zinsser, Hans
Castaneda, M. Ruiz
author_facet Zinsser, Hans
Castaneda, M. Ruiz
author_sort Zinsser, Hans
collection PubMed
description 1. Vaccines consisting of formalinized Rickettsiae of Mexican typhus fever, obtained by our X-ray rat method, produce definite resistance in guinea pigs to subsequent infection with the virus of this disease. 2. The resistance so produced amounts to complete immunity when the subsequent infectious dose is moderate—that is, consists of typhus blood or of tunica material in reasonable amounts (not more than one-quarter of a tunica—i.e., roughly 100 to 250 infectious doses). When, as in the first experiment, excessive doses of infectious material were given, the vaccination protection was, in two of the three animals, incomplete. 3. Subcutaneous vaccination is fully as effective as intraperitoneal —even when the subsequent infection is intraperitoneal. 4. As in previously reported experiments, the vaccines made with the Mexican organisms conferred only partial and feeble protection against the European virus (Breinl strain).
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spelling pubmed-21322402008-04-18 STUDIES ON TYPHUS FEVER : X. FURTHER EXPERIMENTS ON ACTIVE IMMUNIZATION AGAINST TYPHUS FEVER WITH KILLED RICKETTSIA Zinsser, Hans Castaneda, M. Ruiz J Exp Med Article 1. Vaccines consisting of formalinized Rickettsiae of Mexican typhus fever, obtained by our X-ray rat method, produce definite resistance in guinea pigs to subsequent infection with the virus of this disease. 2. The resistance so produced amounts to complete immunity when the subsequent infectious dose is moderate—that is, consists of typhus blood or of tunica material in reasonable amounts (not more than one-quarter of a tunica—i.e., roughly 100 to 250 infectious doses). When, as in the first experiment, excessive doses of infectious material were given, the vaccination protection was, in two of the three animals, incomplete. 3. Subcutaneous vaccination is fully as effective as intraperitoneal —even when the subsequent infection is intraperitoneal. 4. As in previously reported experiments, the vaccines made with the Mexican organisms conferred only partial and feeble protection against the European virus (Breinl strain). The Rockefeller University Press 1933-02-28 /pmc/articles/PMC2132240/ /pubmed/19870137 Text en Copyright © Copyright, 1933, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Zinsser, Hans
Castaneda, M. Ruiz
STUDIES ON TYPHUS FEVER : X. FURTHER EXPERIMENTS ON ACTIVE IMMUNIZATION AGAINST TYPHUS FEVER WITH KILLED RICKETTSIA
title STUDIES ON TYPHUS FEVER : X. FURTHER EXPERIMENTS ON ACTIVE IMMUNIZATION AGAINST TYPHUS FEVER WITH KILLED RICKETTSIA
title_full STUDIES ON TYPHUS FEVER : X. FURTHER EXPERIMENTS ON ACTIVE IMMUNIZATION AGAINST TYPHUS FEVER WITH KILLED RICKETTSIA
title_fullStr STUDIES ON TYPHUS FEVER : X. FURTHER EXPERIMENTS ON ACTIVE IMMUNIZATION AGAINST TYPHUS FEVER WITH KILLED RICKETTSIA
title_full_unstemmed STUDIES ON TYPHUS FEVER : X. FURTHER EXPERIMENTS ON ACTIVE IMMUNIZATION AGAINST TYPHUS FEVER WITH KILLED RICKETTSIA
title_short STUDIES ON TYPHUS FEVER : X. FURTHER EXPERIMENTS ON ACTIVE IMMUNIZATION AGAINST TYPHUS FEVER WITH KILLED RICKETTSIA
title_sort studies on typhus fever : x. further experiments on active immunization against typhus fever with killed rickettsia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132240/
https://www.ncbi.nlm.nih.gov/pubmed/19870137
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