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OBSERVATIONS ON THE IMMUNOLOGICAL RELATION OF POLIOMYELITIS TO LOUPING ILL

The results of the work presented in the present paper show that louping ill and poliomyelitis immunologically are not closely related. Although relatively few experiments were performed, the data obtained were sufficiently decisive for our purposes. Certainly nothing was found to indicate that one...

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Detalles Bibliográficos
Autores principales: Schwentker, F. F., Rivers, Thomas M., Finkelstein, M. H.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1933
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132268/
https://www.ncbi.nlm.nih.gov/pubmed/19870172
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author Schwentker, F. F.
Rivers, Thomas M.
Finkelstein, M. H.
author_facet Schwentker, F. F.
Rivers, Thomas M.
Finkelstein, M. H.
author_sort Schwentker, F. F.
collection PubMed
description The results of the work presented in the present paper show that louping ill and poliomyelitis immunologically are not closely related. Although relatively few experiments were performed, the data obtained were sufficiently decisive for our purposes. Certainly nothing was found to indicate that one might be able to immunize human beings against poliomyelitis by the use of louping ill virus. In addition to the negative findings, a certain amount of useful information was also secured, namely, (1) monkeys can be solidly immunized against louping ill by intraperitoneal injections of virus and partially protected by intramuscular administrations of the active agent, (2) during the process of immunization no signs of involvement of the central nervous system are manifested, and (3) sera from monkeys immunized in the manner described contain antibodies capable of neutralizing the virus.
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spelling pubmed-21322682008-04-18 OBSERVATIONS ON THE IMMUNOLOGICAL RELATION OF POLIOMYELITIS TO LOUPING ILL Schwentker, F. F. Rivers, Thomas M. Finkelstein, M. H. J Exp Med Article The results of the work presented in the present paper show that louping ill and poliomyelitis immunologically are not closely related. Although relatively few experiments were performed, the data obtained were sufficiently decisive for our purposes. Certainly nothing was found to indicate that one might be able to immunize human beings against poliomyelitis by the use of louping ill virus. In addition to the negative findings, a certain amount of useful information was also secured, namely, (1) monkeys can be solidly immunized against louping ill by intraperitoneal injections of virus and partially protected by intramuscular administrations of the active agent, (2) during the process of immunization no signs of involvement of the central nervous system are manifested, and (3) sera from monkeys immunized in the manner described contain antibodies capable of neutralizing the virus. The Rockefeller University Press 1933-05-31 /pmc/articles/PMC2132268/ /pubmed/19870172 Text en Copyright © Copyright, 1933, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Schwentker, F. F.
Rivers, Thomas M.
Finkelstein, M. H.
OBSERVATIONS ON THE IMMUNOLOGICAL RELATION OF POLIOMYELITIS TO LOUPING ILL
title OBSERVATIONS ON THE IMMUNOLOGICAL RELATION OF POLIOMYELITIS TO LOUPING ILL
title_full OBSERVATIONS ON THE IMMUNOLOGICAL RELATION OF POLIOMYELITIS TO LOUPING ILL
title_fullStr OBSERVATIONS ON THE IMMUNOLOGICAL RELATION OF POLIOMYELITIS TO LOUPING ILL
title_full_unstemmed OBSERVATIONS ON THE IMMUNOLOGICAL RELATION OF POLIOMYELITIS TO LOUPING ILL
title_short OBSERVATIONS ON THE IMMUNOLOGICAL RELATION OF POLIOMYELITIS TO LOUPING ILL
title_sort observations on the immunological relation of poliomyelitis to louping ill
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132268/
https://www.ncbi.nlm.nih.gov/pubmed/19870172
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