CONCENTRATION OF THE GONADOTROPIC HORMONE IN PREGNANT MARE'S SERUM

The gonadotropic hormone of the blood of the pregnant mare has been greatly concentrated by adsorption on active aluminum hydroxide followed by elution. The preparations so obtained gave demonstrable gonadotropic effects within 100 hours in 21 day old female mice following three subcutaneous injecti...

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Detalles Bibliográficos
Autores principales: Evans, Herbert M., Gustus, Edwin L., Simpson, Miriam E.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1933
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132317/
https://www.ncbi.nlm.nih.gov/pubmed/19870216
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author Evans, Herbert M.
Gustus, Edwin L.
Simpson, Miriam E.
author_facet Evans, Herbert M.
Gustus, Edwin L.
Simpson, Miriam E.
author_sort Evans, Herbert M.
collection PubMed
description The gonadotropic hormone of the blood of the pregnant mare has been greatly concentrated by adsorption on active aluminum hydroxide followed by elution. The preparations so obtained gave demonstrable gonadotropic effects within 100 hours in 21 day old female mice following three subcutaneous injections of 0.001 mg. in 1 cc. of physiological saline. As is well known, other gonadotropic substances do not cause conspicuous development of the male gonads but injections of comparatively large doses of these preparations into immature male rats caused marked development of the testes, which in 10 days were trebled in weight. An astonishing increase in the weight of the seminal vesicles resulted, for these organs were approximately 75 times heavier than in controls.
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spelling pubmed-21323172008-04-18 CONCENTRATION OF THE GONADOTROPIC HORMONE IN PREGNANT MARE'S SERUM Evans, Herbert M. Gustus, Edwin L. Simpson, Miriam E. J Exp Med Article The gonadotropic hormone of the blood of the pregnant mare has been greatly concentrated by adsorption on active aluminum hydroxide followed by elution. The preparations so obtained gave demonstrable gonadotropic effects within 100 hours in 21 day old female mice following three subcutaneous injections of 0.001 mg. in 1 cc. of physiological saline. As is well known, other gonadotropic substances do not cause conspicuous development of the male gonads but injections of comparatively large doses of these preparations into immature male rats caused marked development of the testes, which in 10 days were trebled in weight. An astonishing increase in the weight of the seminal vesicles resulted, for these organs were approximately 75 times heavier than in controls. The Rockefeller University Press 1933-10-31 /pmc/articles/PMC2132317/ /pubmed/19870216 Text en Copyright © Copyright, 1933, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Evans, Herbert M.
Gustus, Edwin L.
Simpson, Miriam E.
CONCENTRATION OF THE GONADOTROPIC HORMONE IN PREGNANT MARE'S SERUM
title CONCENTRATION OF THE GONADOTROPIC HORMONE IN PREGNANT MARE'S SERUM
title_full CONCENTRATION OF THE GONADOTROPIC HORMONE IN PREGNANT MARE'S SERUM
title_fullStr CONCENTRATION OF THE GONADOTROPIC HORMONE IN PREGNANT MARE'S SERUM
title_full_unstemmed CONCENTRATION OF THE GONADOTROPIC HORMONE IN PREGNANT MARE'S SERUM
title_short CONCENTRATION OF THE GONADOTROPIC HORMONE IN PREGNANT MARE'S SERUM
title_sort concentration of the gonadotropic hormone in pregnant mare's serum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132317/
https://www.ncbi.nlm.nih.gov/pubmed/19870216
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AT gustusedwinl concentrationofthegonadotropichormoneinpregnantmaresserum
AT simpsonmiriame concentrationofthegonadotropichormoneinpregnantmaresserum

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