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FURTHER STUDIES ON THE HYPOPHYSEAL SUBSTANCE GIVING INCREASED GONADOTROPIC EFFECTS WHEN COMBINED WITH PROLAN

The hypophyseal substance—the synergic factor—which gives increased gonadotropic effects when combined with prolan has been shown to itself possess a definite though slight gonadotropic activity. It produces transitory follicular enlargement within 24–48 hours, which, however, regresses at once on c...

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Detalles Bibliográficos
Autores principales: Evans, Herbert M., Simpson, Miriam E., Austin, Paul R.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1933
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132325/
https://www.ncbi.nlm.nih.gov/pubmed/19870214
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author Evans, Herbert M.
Simpson, Miriam E.
Austin, Paul R.
author_facet Evans, Herbert M.
Simpson, Miriam E.
Austin, Paul R.
author_sort Evans, Herbert M.
collection PubMed
description The hypophyseal substance—the synergic factor—which gives increased gonadotropic effects when combined with prolan has been shown to itself possess a definite though slight gonadotropic activity. It produces transitory follicular enlargement within 24–48 hours, which, however, regresses at once on cessation of treatment so that by the end of the 4th day the ovary again approximates its infantile weight. The synergic principle indeed provokes only moderate ovarian development when administered in 100 times the dose necessary to demonstrate the activation phenomenon. By means of isoelectric precipitation or by means of tryptic and ereptic digestion, fractions containing the synergic principle were freed of many contaminants, in particular of the antagonistic factor. The synergic principle has been shown to be unaffected by digestion with trypsin or trypsin followed by a short digestion with erepsin, but the action of pepsin inactivated the material. A preparation of the active substance has been obtained which is potent in a total dose of 27 gamma.
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spelling pubmed-21323252008-04-18 FURTHER STUDIES ON THE HYPOPHYSEAL SUBSTANCE GIVING INCREASED GONADOTROPIC EFFECTS WHEN COMBINED WITH PROLAN Evans, Herbert M. Simpson, Miriam E. Austin, Paul R. J Exp Med Article The hypophyseal substance—the synergic factor—which gives increased gonadotropic effects when combined with prolan has been shown to itself possess a definite though slight gonadotropic activity. It produces transitory follicular enlargement within 24–48 hours, which, however, regresses at once on cessation of treatment so that by the end of the 4th day the ovary again approximates its infantile weight. The synergic principle indeed provokes only moderate ovarian development when administered in 100 times the dose necessary to demonstrate the activation phenomenon. By means of isoelectric precipitation or by means of tryptic and ereptic digestion, fractions containing the synergic principle were freed of many contaminants, in particular of the antagonistic factor. The synergic principle has been shown to be unaffected by digestion with trypsin or trypsin followed by a short digestion with erepsin, but the action of pepsin inactivated the material. A preparation of the active substance has been obtained which is potent in a total dose of 27 gamma. The Rockefeller University Press 1933-10-31 /pmc/articles/PMC2132325/ /pubmed/19870214 Text en Copyright © Copyright, 1933, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Evans, Herbert M.
Simpson, Miriam E.
Austin, Paul R.
FURTHER STUDIES ON THE HYPOPHYSEAL SUBSTANCE GIVING INCREASED GONADOTROPIC EFFECTS WHEN COMBINED WITH PROLAN
title FURTHER STUDIES ON THE HYPOPHYSEAL SUBSTANCE GIVING INCREASED GONADOTROPIC EFFECTS WHEN COMBINED WITH PROLAN
title_full FURTHER STUDIES ON THE HYPOPHYSEAL SUBSTANCE GIVING INCREASED GONADOTROPIC EFFECTS WHEN COMBINED WITH PROLAN
title_fullStr FURTHER STUDIES ON THE HYPOPHYSEAL SUBSTANCE GIVING INCREASED GONADOTROPIC EFFECTS WHEN COMBINED WITH PROLAN
title_full_unstemmed FURTHER STUDIES ON THE HYPOPHYSEAL SUBSTANCE GIVING INCREASED GONADOTROPIC EFFECTS WHEN COMBINED WITH PROLAN
title_short FURTHER STUDIES ON THE HYPOPHYSEAL SUBSTANCE GIVING INCREASED GONADOTROPIC EFFECTS WHEN COMBINED WITH PROLAN
title_sort further studies on the hypophyseal substance giving increased gonadotropic effects when combined with prolan
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132325/
https://www.ncbi.nlm.nih.gov/pubmed/19870214
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