Cargando…
ON THE USE OF ADSORBENTS IN IMMUNIZATIONS WITH HAPTENS
Experiments are described which confirm the observation of Gonzalez and Armangué that heterogenetic extracts can be made antigenic by adsorption to inorganic materials. With fractions of the original extracts from which a part of inactive material had been removed no such enhancement was observed, w...
Autor principal: | |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
1934
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132331/ https://www.ncbi.nlm.nih.gov/pubmed/19870260 |
_version_ | 1782142423395205120 |
---|---|
author | Jacobs, John |
author_facet | Jacobs, John |
author_sort | Jacobs, John |
collection | PubMed |
description | Experiments are described which confirm the observation of Gonzalez and Armangué that heterogenetic extracts can be made antigenic by adsorption to inorganic materials. With fractions of the original extracts from which a part of inactive material had been removed no such enhancement was observed, whereas with foreign protein an activation was still possible. Carbohydrate preparations behaved similarly in that purification, perhaps loss of protein, was accompanied by a distinct decrease in antigenicity after adsorption. The activity of a but slightly antigenic heteroalbumose preparation was markedly increased after adsorption to charcoal and alum. The most reasonable explanation for the effects observed by Gonzalez and Armangué, and Zozaya, seems to be that a preexisting antigenic capacity has been enhanced by the use of adsorbents. The experiments reported here support the view that these effects are influenced significantly by the presence of substances other than those of a specific nature. |
format | Text |
id | pubmed-2132331 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1934 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21323312008-04-18 ON THE USE OF ADSORBENTS IN IMMUNIZATIONS WITH HAPTENS Jacobs, John J Exp Med Article Experiments are described which confirm the observation of Gonzalez and Armangué that heterogenetic extracts can be made antigenic by adsorption to inorganic materials. With fractions of the original extracts from which a part of inactive material had been removed no such enhancement was observed, whereas with foreign protein an activation was still possible. Carbohydrate preparations behaved similarly in that purification, perhaps loss of protein, was accompanied by a distinct decrease in antigenicity after adsorption. The activity of a but slightly antigenic heteroalbumose preparation was markedly increased after adsorption to charcoal and alum. The most reasonable explanation for the effects observed by Gonzalez and Armangué, and Zozaya, seems to be that a preexisting antigenic capacity has been enhanced by the use of adsorbents. The experiments reported here support the view that these effects are influenced significantly by the presence of substances other than those of a specific nature. The Rockefeller University Press 1934-03-31 /pmc/articles/PMC2132331/ /pubmed/19870260 Text en Copyright © Copyright, 1934, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Jacobs, John ON THE USE OF ADSORBENTS IN IMMUNIZATIONS WITH HAPTENS |
title | ON THE USE OF ADSORBENTS IN IMMUNIZATIONS WITH HAPTENS |
title_full | ON THE USE OF ADSORBENTS IN IMMUNIZATIONS WITH HAPTENS |
title_fullStr | ON THE USE OF ADSORBENTS IN IMMUNIZATIONS WITH HAPTENS |
title_full_unstemmed | ON THE USE OF ADSORBENTS IN IMMUNIZATIONS WITH HAPTENS |
title_short | ON THE USE OF ADSORBENTS IN IMMUNIZATIONS WITH HAPTENS |
title_sort | on the use of adsorbents in immunizations with haptens |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132331/ https://www.ncbi.nlm.nih.gov/pubmed/19870260 |
work_keys_str_mv | AT jacobsjohn ontheuseofadsorbentsinimmunizationswithhaptens |