EXPERIMENTAL TYPE III PNEUMOCOCCUS PNEUMONIA IN MONKEYS : II. TREATMENT WITH AN ENZYME WHICH DECOMPOSES THE SPECIFIC CAPSULAR POLYSACCHARIDE OF PNEUMOCOCCUS TYPE III

The effects of specific enzyme therapy upon experimental Type III pneumococcus pneumonia in monkeys were studied by comparing the course and outcome of the disease in treated animals with that in animals which received no therapeutic aid. Enzyme treatment was found to exert a distinctly favorable in...

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Detalles Bibliográficos
Autores principales: Francis, Thomas, Terrell, Edward E., Dubos, René, Avery, Oswald T.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1934
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132365/
https://www.ncbi.nlm.nih.gov/pubmed/19870270
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author Francis, Thomas
Terrell, Edward E.
Dubos, René
Avery, Oswald T.
author_facet Francis, Thomas
Terrell, Edward E.
Dubos, René
Avery, Oswald T.
author_sort Francis, Thomas
collection PubMed
description The effects of specific enzyme therapy upon experimental Type III pneumococcus pneumonia in monkeys were studied by comparing the course and outcome of the disease in treated animals with that in animals which received no therapeutic aid. Enzyme treatment was found to exert a distinctly favorable influence upon the experimental pneumonia. Treatment was followed by cessation of spread of the pneumonic lesion, sterilization of the blood, and early recovery, except in animals in which the severity of the disease was extreme. While in the untreated animals a high incidence of empyema and pericarditis was observed, suppurative sequelae were apparently prevented by adequate enzyme therapy. The limitations of the therapeutic action of the specific enzyme in the presence of marked depression of the cellular reaction in infected animals are again emphasized.
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spelling pubmed-21323652008-04-18 EXPERIMENTAL TYPE III PNEUMOCOCCUS PNEUMONIA IN MONKEYS : II. TREATMENT WITH AN ENZYME WHICH DECOMPOSES THE SPECIFIC CAPSULAR POLYSACCHARIDE OF PNEUMOCOCCUS TYPE III Francis, Thomas Terrell, Edward E. Dubos, René Avery, Oswald T. J Exp Med Article The effects of specific enzyme therapy upon experimental Type III pneumococcus pneumonia in monkeys were studied by comparing the course and outcome of the disease in treated animals with that in animals which received no therapeutic aid. Enzyme treatment was found to exert a distinctly favorable influence upon the experimental pneumonia. Treatment was followed by cessation of spread of the pneumonic lesion, sterilization of the blood, and early recovery, except in animals in which the severity of the disease was extreme. While in the untreated animals a high incidence of empyema and pericarditis was observed, suppurative sequelae were apparently prevented by adequate enzyme therapy. The limitations of the therapeutic action of the specific enzyme in the presence of marked depression of the cellular reaction in infected animals are again emphasized. The Rockefeller University Press 1934-04-30 /pmc/articles/PMC2132365/ /pubmed/19870270 Text en Copyright © Copyright, 1934, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Francis, Thomas
Terrell, Edward E.
Dubos, René
Avery, Oswald T.
EXPERIMENTAL TYPE III PNEUMOCOCCUS PNEUMONIA IN MONKEYS : II. TREATMENT WITH AN ENZYME WHICH DECOMPOSES THE SPECIFIC CAPSULAR POLYSACCHARIDE OF PNEUMOCOCCUS TYPE III
title EXPERIMENTAL TYPE III PNEUMOCOCCUS PNEUMONIA IN MONKEYS : II. TREATMENT WITH AN ENZYME WHICH DECOMPOSES THE SPECIFIC CAPSULAR POLYSACCHARIDE OF PNEUMOCOCCUS TYPE III
title_full EXPERIMENTAL TYPE III PNEUMOCOCCUS PNEUMONIA IN MONKEYS : II. TREATMENT WITH AN ENZYME WHICH DECOMPOSES THE SPECIFIC CAPSULAR POLYSACCHARIDE OF PNEUMOCOCCUS TYPE III
title_fullStr EXPERIMENTAL TYPE III PNEUMOCOCCUS PNEUMONIA IN MONKEYS : II. TREATMENT WITH AN ENZYME WHICH DECOMPOSES THE SPECIFIC CAPSULAR POLYSACCHARIDE OF PNEUMOCOCCUS TYPE III
title_full_unstemmed EXPERIMENTAL TYPE III PNEUMOCOCCUS PNEUMONIA IN MONKEYS : II. TREATMENT WITH AN ENZYME WHICH DECOMPOSES THE SPECIFIC CAPSULAR POLYSACCHARIDE OF PNEUMOCOCCUS TYPE III
title_short EXPERIMENTAL TYPE III PNEUMOCOCCUS PNEUMONIA IN MONKEYS : II. TREATMENT WITH AN ENZYME WHICH DECOMPOSES THE SPECIFIC CAPSULAR POLYSACCHARIDE OF PNEUMOCOCCUS TYPE III
title_sort experimental type iii pneumococcus pneumonia in monkeys : ii. treatment with an enzyme which decomposes the specific capsular polysaccharide of pneumococcus type iii
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132365/
https://www.ncbi.nlm.nih.gov/pubmed/19870270
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