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EXPERIMENTAL TYPE III PNEUMOCOCCUS PNEUMONIA IN MONKEYS : I. PRODUCTION AND CLINICAL COURSE

It has been possible by the intratracheal or intrabronchial inoculation of Type III Pneumococcus to produce in monkeys of the M. cynomolgos species an experimental pneumonia which in its clinical aspects closely resembles pneumococcus lobar pneumonia in man. The experimental disease is characterized...

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Detalles Bibliográficos
Autores principales: Francis, Thomas, Terrell, Edward E.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1934
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132367/
https://www.ncbi.nlm.nih.gov/pubmed/19870269
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author Francis, Thomas
Terrell, Edward E.
author_facet Francis, Thomas
Terrell, Edward E.
author_sort Francis, Thomas
collection PubMed
description It has been possible by the intratracheal or intrabronchial inoculation of Type III Pneumococcus to produce in monkeys of the M. cynomolgos species an experimental pneumonia which in its clinical aspects closely resembles pneumococcus lobar pneumonia in man. The experimental disease is characterized by the development of a well localized pulmonary lesion of lobar distribution which tends to spread, the frequent occurrence of septicemia, a sustained fever, and the termination of the infection after a variable interval, in recovery or death of the animal. Wide variations in the severity of the disease in different monkeys have been noted. These variations appear to be due primarily to differences in the resistance of individual animals. The height of the septicemia accompanying the experimental pneumonia has been found to be the most valuable objective index of the probable outcome of the disease. Other factors which may influence the course and outcome of the disease are discussed.
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spelling pubmed-21323672008-04-18 EXPERIMENTAL TYPE III PNEUMOCOCCUS PNEUMONIA IN MONKEYS : I. PRODUCTION AND CLINICAL COURSE Francis, Thomas Terrell, Edward E. J Exp Med Article It has been possible by the intratracheal or intrabronchial inoculation of Type III Pneumococcus to produce in monkeys of the M. cynomolgos species an experimental pneumonia which in its clinical aspects closely resembles pneumococcus lobar pneumonia in man. The experimental disease is characterized by the development of a well localized pulmonary lesion of lobar distribution which tends to spread, the frequent occurrence of septicemia, a sustained fever, and the termination of the infection after a variable interval, in recovery or death of the animal. Wide variations in the severity of the disease in different monkeys have been noted. These variations appear to be due primarily to differences in the resistance of individual animals. The height of the septicemia accompanying the experimental pneumonia has been found to be the most valuable objective index of the probable outcome of the disease. Other factors which may influence the course and outcome of the disease are discussed. The Rockefeller University Press 1934-04-30 /pmc/articles/PMC2132367/ /pubmed/19870269 Text en Copyright © Copyright, 1934, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Francis, Thomas
Terrell, Edward E.
EXPERIMENTAL TYPE III PNEUMOCOCCUS PNEUMONIA IN MONKEYS : I. PRODUCTION AND CLINICAL COURSE
title EXPERIMENTAL TYPE III PNEUMOCOCCUS PNEUMONIA IN MONKEYS : I. PRODUCTION AND CLINICAL COURSE
title_full EXPERIMENTAL TYPE III PNEUMOCOCCUS PNEUMONIA IN MONKEYS : I. PRODUCTION AND CLINICAL COURSE
title_fullStr EXPERIMENTAL TYPE III PNEUMOCOCCUS PNEUMONIA IN MONKEYS : I. PRODUCTION AND CLINICAL COURSE
title_full_unstemmed EXPERIMENTAL TYPE III PNEUMOCOCCUS PNEUMONIA IN MONKEYS : I. PRODUCTION AND CLINICAL COURSE
title_short EXPERIMENTAL TYPE III PNEUMOCOCCUS PNEUMONIA IN MONKEYS : I. PRODUCTION AND CLINICAL COURSE
title_sort experimental type iii pneumococcus pneumonia in monkeys : i. production and clinical course
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132367/
https://www.ncbi.nlm.nih.gov/pubmed/19870269
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