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EXPERIMENTAL TYPE III PNEUMOCOCCUS PNEUMONIA IN MONKEYS : I. PRODUCTION AND CLINICAL COURSE
It has been possible by the intratracheal or intrabronchial inoculation of Type III Pneumococcus to produce in monkeys of the M. cynomolgos species an experimental pneumonia which in its clinical aspects closely resembles pneumococcus lobar pneumonia in man. The experimental disease is characterized...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
1934
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132367/ https://www.ncbi.nlm.nih.gov/pubmed/19870269 |
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author | Francis, Thomas Terrell, Edward E. |
author_facet | Francis, Thomas Terrell, Edward E. |
author_sort | Francis, Thomas |
collection | PubMed |
description | It has been possible by the intratracheal or intrabronchial inoculation of Type III Pneumococcus to produce in monkeys of the M. cynomolgos species an experimental pneumonia which in its clinical aspects closely resembles pneumococcus lobar pneumonia in man. The experimental disease is characterized by the development of a well localized pulmonary lesion of lobar distribution which tends to spread, the frequent occurrence of septicemia, a sustained fever, and the termination of the infection after a variable interval, in recovery or death of the animal. Wide variations in the severity of the disease in different monkeys have been noted. These variations appear to be due primarily to differences in the resistance of individual animals. The height of the septicemia accompanying the experimental pneumonia has been found to be the most valuable objective index of the probable outcome of the disease. Other factors which may influence the course and outcome of the disease are discussed. |
format | Text |
id | pubmed-2132367 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1934 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21323672008-04-18 EXPERIMENTAL TYPE III PNEUMOCOCCUS PNEUMONIA IN MONKEYS : I. PRODUCTION AND CLINICAL COURSE Francis, Thomas Terrell, Edward E. J Exp Med Article It has been possible by the intratracheal or intrabronchial inoculation of Type III Pneumococcus to produce in monkeys of the M. cynomolgos species an experimental pneumonia which in its clinical aspects closely resembles pneumococcus lobar pneumonia in man. The experimental disease is characterized by the development of a well localized pulmonary lesion of lobar distribution which tends to spread, the frequent occurrence of septicemia, a sustained fever, and the termination of the infection after a variable interval, in recovery or death of the animal. Wide variations in the severity of the disease in different monkeys have been noted. These variations appear to be due primarily to differences in the resistance of individual animals. The height of the septicemia accompanying the experimental pneumonia has been found to be the most valuable objective index of the probable outcome of the disease. Other factors which may influence the course and outcome of the disease are discussed. The Rockefeller University Press 1934-04-30 /pmc/articles/PMC2132367/ /pubmed/19870269 Text en Copyright © Copyright, 1934, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Francis, Thomas Terrell, Edward E. EXPERIMENTAL TYPE III PNEUMOCOCCUS PNEUMONIA IN MONKEYS : I. PRODUCTION AND CLINICAL COURSE |
title | EXPERIMENTAL TYPE III PNEUMOCOCCUS PNEUMONIA IN MONKEYS : I. PRODUCTION AND CLINICAL COURSE |
title_full | EXPERIMENTAL TYPE III PNEUMOCOCCUS PNEUMONIA IN MONKEYS : I. PRODUCTION AND CLINICAL COURSE |
title_fullStr | EXPERIMENTAL TYPE III PNEUMOCOCCUS PNEUMONIA IN MONKEYS : I. PRODUCTION AND CLINICAL COURSE |
title_full_unstemmed | EXPERIMENTAL TYPE III PNEUMOCOCCUS PNEUMONIA IN MONKEYS : I. PRODUCTION AND CLINICAL COURSE |
title_short | EXPERIMENTAL TYPE III PNEUMOCOCCUS PNEUMONIA IN MONKEYS : I. PRODUCTION AND CLINICAL COURSE |
title_sort | experimental type iii pneumococcus pneumonia in monkeys : i. production and clinical course |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132367/ https://www.ncbi.nlm.nih.gov/pubmed/19870269 |
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