SEROLOGICAL STUDIES ON AZOPROTEINS : ANTIGENS CONTAINING AZOCOMPONENTS WITH ALIPHATIC SIDE CHAINS

A study was made of the specificity of artificial compound-antigens containing aliphatic chains. Striking specificity was exhibited in the reactions of compounds with short chains containing a carboxyl group; for instance succinic acid could be differentiated from malonic or glutaric acid which cont...

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Detalles Bibliográficos
Autores principales: Landsteiner, E., van der Scheer, J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1934
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132373/
https://www.ncbi.nlm.nih.gov/pubmed/19870277
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author Landsteiner, E.
van der Scheer, J.
author_facet Landsteiner, E.
van der Scheer, J.
author_sort Landsteiner, E.
collection PubMed
description A study was made of the specificity of artificial compound-antigens containing aliphatic chains. Striking specificity was exhibited in the reactions of compounds with short chains containing a carboxyl group; for instance succinic acid could be differentiated from malonic or glutaric acid which contain one fewer and one more carbon atom respectively. With the substances containing longer chains, reactions were observed which, although specific to a certain extent, appear to depend mainly on the general physicochemical properties of long aliphatic chains. With a limited number of substances the influence of substituents —halogen, OH, NH(2)—on the serological specificity was investigated. By means of inhibition reactions it was possible to demonstrate the serological specificity of cis-trans isomers such as maleic and fumaric acid.
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spelling pubmed-21323732008-04-18 SEROLOGICAL STUDIES ON AZOPROTEINS : ANTIGENS CONTAINING AZOCOMPONENTS WITH ALIPHATIC SIDE CHAINS Landsteiner, E. van der Scheer, J. J Exp Med Article A study was made of the specificity of artificial compound-antigens containing aliphatic chains. Striking specificity was exhibited in the reactions of compounds with short chains containing a carboxyl group; for instance succinic acid could be differentiated from malonic or glutaric acid which contain one fewer and one more carbon atom respectively. With the substances containing longer chains, reactions were observed which, although specific to a certain extent, appear to depend mainly on the general physicochemical properties of long aliphatic chains. With a limited number of substances the influence of substituents —halogen, OH, NH(2)—on the serological specificity was investigated. By means of inhibition reactions it was possible to demonstrate the serological specificity of cis-trans isomers such as maleic and fumaric acid. The Rockefeller University Press 1934-05-31 /pmc/articles/PMC2132373/ /pubmed/19870277 Text en Copyright © Copyright, 1934, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Landsteiner, E.
van der Scheer, J.
SEROLOGICAL STUDIES ON AZOPROTEINS : ANTIGENS CONTAINING AZOCOMPONENTS WITH ALIPHATIC SIDE CHAINS
title SEROLOGICAL STUDIES ON AZOPROTEINS : ANTIGENS CONTAINING AZOCOMPONENTS WITH ALIPHATIC SIDE CHAINS
title_full SEROLOGICAL STUDIES ON AZOPROTEINS : ANTIGENS CONTAINING AZOCOMPONENTS WITH ALIPHATIC SIDE CHAINS
title_fullStr SEROLOGICAL STUDIES ON AZOPROTEINS : ANTIGENS CONTAINING AZOCOMPONENTS WITH ALIPHATIC SIDE CHAINS
title_full_unstemmed SEROLOGICAL STUDIES ON AZOPROTEINS : ANTIGENS CONTAINING AZOCOMPONENTS WITH ALIPHATIC SIDE CHAINS
title_short SEROLOGICAL STUDIES ON AZOPROTEINS : ANTIGENS CONTAINING AZOCOMPONENTS WITH ALIPHATIC SIDE CHAINS
title_sort serological studies on azoproteins : antigens containing azocomponents with aliphatic side chains
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132373/
https://www.ncbi.nlm.nih.gov/pubmed/19870277
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