BIOLOGICAL STUDIES OF THE TUBERCLE BACILLUS : III. DISSOCIATION AND PATHOGENICITY OF THE R AND S VARIANTS OF THE HUMAN TUBERCLE BACILLUS (H(37))

1. The H(37) strain of human tubercle bacillus has been dissociated into two variants,—the R, or avirulent, and the S, or virulent, variants. 2. When their dissociation is complete, colony morphology for each is distinctive and typical. 3. The morphology of the individual bacilli of the two variants...

Descripción completa

Detalles Bibliográficos
Autores principales: Steenken, W., Oatway, W. H., Petroff, S. A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1934
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132400/
https://www.ncbi.nlm.nih.gov/pubmed/19870319
_version_ 1782142439849459712
author Steenken, W.
Oatway, W. H.
Petroff, S. A.
author_facet Steenken, W.
Oatway, W. H.
Petroff, S. A.
author_sort Steenken, W.
collection PubMed
description 1. The H(37) strain of human tubercle bacillus has been dissociated into two variants,—the R, or avirulent, and the S, or virulent, variants. 2. When their dissociation is complete, colony morphology for each is distinctive and typical. 3. The morphology of the individual bacilli of the two variants is different and characteristic. 4. The R variant develops best in an acid medium; the S develops best in an alkaline medium. 5. A method of assortment to facilitate the procedure of forced dissociation has been described. 6. The difference in virulence has been proven by observations on the pathogenesis of the variants.
format Text
id pubmed-2132400
institution National Center for Biotechnology Information
language English
publishDate 1934
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21324002008-04-18 BIOLOGICAL STUDIES OF THE TUBERCLE BACILLUS : III. DISSOCIATION AND PATHOGENICITY OF THE R AND S VARIANTS OF THE HUMAN TUBERCLE BACILLUS (H(37)) Steenken, W. Oatway, W. H. Petroff, S. A. J Exp Med Article 1. The H(37) strain of human tubercle bacillus has been dissociated into two variants,—the R, or avirulent, and the S, or virulent, variants. 2. When their dissociation is complete, colony morphology for each is distinctive and typical. 3. The morphology of the individual bacilli of the two variants is different and characteristic. 4. The R variant develops best in an acid medium; the S develops best in an alkaline medium. 5. A method of assortment to facilitate the procedure of forced dissociation has been described. 6. The difference in virulence has been proven by observations on the pathogenesis of the variants. The Rockefeller University Press 1934-09-30 /pmc/articles/PMC2132400/ /pubmed/19870319 Text en Copyright © Copyright, 1934, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Steenken, W.
Oatway, W. H.
Petroff, S. A.
BIOLOGICAL STUDIES OF THE TUBERCLE BACILLUS : III. DISSOCIATION AND PATHOGENICITY OF THE R AND S VARIANTS OF THE HUMAN TUBERCLE BACILLUS (H(37))
title BIOLOGICAL STUDIES OF THE TUBERCLE BACILLUS : III. DISSOCIATION AND PATHOGENICITY OF THE R AND S VARIANTS OF THE HUMAN TUBERCLE BACILLUS (H(37))
title_full BIOLOGICAL STUDIES OF THE TUBERCLE BACILLUS : III. DISSOCIATION AND PATHOGENICITY OF THE R AND S VARIANTS OF THE HUMAN TUBERCLE BACILLUS (H(37))
title_fullStr BIOLOGICAL STUDIES OF THE TUBERCLE BACILLUS : III. DISSOCIATION AND PATHOGENICITY OF THE R AND S VARIANTS OF THE HUMAN TUBERCLE BACILLUS (H(37))
title_full_unstemmed BIOLOGICAL STUDIES OF THE TUBERCLE BACILLUS : III. DISSOCIATION AND PATHOGENICITY OF THE R AND S VARIANTS OF THE HUMAN TUBERCLE BACILLUS (H(37))
title_short BIOLOGICAL STUDIES OF THE TUBERCLE BACILLUS : III. DISSOCIATION AND PATHOGENICITY OF THE R AND S VARIANTS OF THE HUMAN TUBERCLE BACILLUS (H(37))
title_sort biological studies of the tubercle bacillus : iii. dissociation and pathogenicity of the r and s variants of the human tubercle bacillus (h(37))
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132400/
https://www.ncbi.nlm.nih.gov/pubmed/19870319
work_keys_str_mv AT steenkenw biologicalstudiesofthetuberclebacillusiiidissociationandpathogenicityoftherandsvariantsofthehumantuberclebacillush37
AT oatwaywh biologicalstudiesofthetuberclebacillusiiidissociationandpathogenicityoftherandsvariantsofthehumantuberclebacillush37
AT petroffsa biologicalstudiesofthetuberclebacillusiiidissociationandpathogenicityoftherandsvariantsofthehumantuberclebacillush37

Ejemplares similares