CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS : IX. THE SPECIFICITY OF ANTIGENS PREPARED BY COMBINING THEp-AMINOPHENOL GLYCOSIDES OF DISACCHARIDES WITH PROTEIN

The results of the present study indicate that by means of serological reactions it is possible to differentiate selectively the p-aminophenol glycosides of maltose, cellobiose, gentiobiose, and lactose. The immunological specificity of disaccharide-protein antigens prepared from these derivatives,...

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Detalles Bibliográficos
Autores principales: Goebel, Walther F., Avery, Oswald T., Babers, Frank H.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1934
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132428/
https://www.ncbi.nlm.nih.gov/pubmed/19870325
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author Goebel, Walther F.
Avery, Oswald T.
Babers, Frank H.
author_facet Goebel, Walther F.
Avery, Oswald T.
Babers, Frank H.
author_sort Goebel, Walther F.
collection PubMed
description The results of the present study indicate that by means of serological reactions it is possible to differentiate selectively the p-aminophenol glycosides of maltose, cellobiose, gentiobiose, and lactose. The immunological specificity of disaccharide-protein antigens prepared from these derivatives, irrespective of the nature of the conjoined protein, is determined by (1) the glycoside molecule as a whole, (2) the configuration of the terminal hexose molecule, and (3) the position of linkage of the two hexose units in the carbohydrate radical. The specificity of the antibodies induced by the disaccharide antigens appears to be more sharply defined when the configuration of the terminal hexose is of the β rather than of the α type.
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spelling pubmed-21324282008-04-18 CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS : IX. THE SPECIFICITY OF ANTIGENS PREPARED BY COMBINING THEp-AMINOPHENOL GLYCOSIDES OF DISACCHARIDES WITH PROTEIN Goebel, Walther F. Avery, Oswald T. Babers, Frank H. J Exp Med Article The results of the present study indicate that by means of serological reactions it is possible to differentiate selectively the p-aminophenol glycosides of maltose, cellobiose, gentiobiose, and lactose. The immunological specificity of disaccharide-protein antigens prepared from these derivatives, irrespective of the nature of the conjoined protein, is determined by (1) the glycoside molecule as a whole, (2) the configuration of the terminal hexose molecule, and (3) the position of linkage of the two hexose units in the carbohydrate radical. The specificity of the antibodies induced by the disaccharide antigens appears to be more sharply defined when the configuration of the terminal hexose is of the β rather than of the α type. The Rockefeller University Press 1934-10-31 /pmc/articles/PMC2132428/ /pubmed/19870325 Text en Copyright © Copyright, 1934, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Goebel, Walther F.
Avery, Oswald T.
Babers, Frank H.
CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS : IX. THE SPECIFICITY OF ANTIGENS PREPARED BY COMBINING THEp-AMINOPHENOL GLYCOSIDES OF DISACCHARIDES WITH PROTEIN
title CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS : IX. THE SPECIFICITY OF ANTIGENS PREPARED BY COMBINING THEp-AMINOPHENOL GLYCOSIDES OF DISACCHARIDES WITH PROTEIN
title_full CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS : IX. THE SPECIFICITY OF ANTIGENS PREPARED BY COMBINING THEp-AMINOPHENOL GLYCOSIDES OF DISACCHARIDES WITH PROTEIN
title_fullStr CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS : IX. THE SPECIFICITY OF ANTIGENS PREPARED BY COMBINING THEp-AMINOPHENOL GLYCOSIDES OF DISACCHARIDES WITH PROTEIN
title_full_unstemmed CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS : IX. THE SPECIFICITY OF ANTIGENS PREPARED BY COMBINING THEp-AMINOPHENOL GLYCOSIDES OF DISACCHARIDES WITH PROTEIN
title_short CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS : IX. THE SPECIFICITY OF ANTIGENS PREPARED BY COMBINING THEp-AMINOPHENOL GLYCOSIDES OF DISACCHARIDES WITH PROTEIN
title_sort chemo-immunological studies on conjugated carbohydrate-proteins : ix. the specificity of antigens prepared by combining thep-aminophenol glycosides of disaccharides with protein
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132428/
https://www.ncbi.nlm.nih.gov/pubmed/19870325
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AT averyoswaldt chemoimmunologicalstudiesonconjugatedcarbohydrateproteinsixthespecificityofantigenspreparedbycombiningthepaminophenolglycosidesofdisaccharideswithprotein
AT babersfrankh chemoimmunologicalstudiesonconjugatedcarbohydrateproteinsixthespecificityofantigenspreparedbycombiningthepaminophenolglycosidesofdisaccharideswithprotein

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