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Cell Cycle–coupled Relocation of Types I and II Topoisomerases and Modulation of Catalytic Enzyme Activities

We visualized DNA topoisomerases in A431 cells and isolated chromosomes by isoenzyme-selective immunofluorescence microscopy. In interphase, topoisomerase I mainly had a homogeneous nuclear distribution. 10–15% of the cells exhibited granular patterns, 30% showed bright intranucleolar patches. Topoi...

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Detalles Bibliográficos
Autores principales:	Meyer, Kay N., Kjeldsen, Eigil, Straub, Tobias, Knudsen, Birgitta R., Hickson, Ian D., Kikuchi, Akihiko, Kreipe, Hans, Boege, Fritz
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 1997
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132491/ https://www.ncbi.nlm.nih.gov/pubmed/9049244

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