Integrin-mediated Activation of MAP Kinase Is Independent of FAK: Evidence for Dual Integrin Signaling Pathways in Fibroblasts

Integrin-mediated cell adhesion causes activation of MAP kinases and increased tyrosine phosphorylation of focal adhesion kinase (FAK). Autophosphorylation of FAK leads to the binding of SH2-domain proteins including Src-family kinases and the Grb2–Sos complex. Since Grb2–Sos is a key regulator of t...

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Autores principales: Lin, Tsung H., Aplin, Andrew E., Shen, Yu, Chen, Qiming, Schaller, Michael, Romer, Lewis, Aukhil, Ikramuddin, Juliano, R.L.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1997
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132513/
https://www.ncbi.nlm.nih.gov/pubmed/9087451

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