A Chromatin-associated Kinesin-related Protein Required for Normal Mitotic Chromosome Segregation in Drosophila

The tiovivo (tio) gene of Drosophila encodes a kinesin-related protein, KLP38B, that colocalizes with condensed chromatin during cell division. Wild-type function of the tio gene product KLP38B is required for normal chromosome segregation during mitosis. Mitotic cells in tio larval brains displayed...

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Detalles Bibliográficos
Autores principales: Molina, Isabel, Baars, Sigrid, Brill, Julie A., Hales, Karen G., Fuller, Margaret T., Ripoll, Pedro
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1997
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132616/
https://www.ncbi.nlm.nih.gov/pubmed/9396743
Descripción
Sumario:The tiovivo (tio) gene of Drosophila encodes a kinesin-related protein, KLP38B, that colocalizes with condensed chromatin during cell division. Wild-type function of the tio gene product KLP38B is required for normal chromosome segregation during mitosis. Mitotic cells in tio larval brains displayed circular mitotic figures, increased ploidy, and abnormal anaphase figures. KLP38B mRNA is maternally provided and expressed in cells about to undergo division. We propose that KLP38B, perhaps redundantly with other chromosome-associated microtubule motor proteins, contributes to interactions between chromosome arms and microtubules important for establishing bipolar attachment of chromosomes and assembly of stable bipolar spindles.

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